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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 45, Issue 10


The −374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients

Geraldo Picheth
  • 1Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Costantino O. Costantini / Fábio O. Pedrosa
  • 3Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tania Leme da Rocha Martinez / Emanuel Maltempi de Souza
  • 5Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-10-10 | DOI: https://doi.org/10.1515/CCLM.2007.273


Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been associated with diabetes, coronary artery disease (CAD) and inflammatory processes. The –374T>A RAGE gene promoter polymorphism was shown to affect gene transcription. The aim of this study was to evaluate the association of the –374T>A polymorphism with the severity of CAD in patients with or without type 2 diabetes mellitus.

Methods: We studied 246 Euro-Brazilians with angiographically defined CAD (stenosis >50%), comprising type 2 diabetic (n=98) and non-diabetic subjects (n=148). Genotyping was performed by PCR-restriction fragment length polymorphism using Tsp509I restriction enzyme.

Results: The AA genotype was associated with a significant decrease in CAD severity estimated by the number of diseased vessels (1.43±0.5 vs. 2.49±1.1; p=0.002) and the Duke score (27.3±10.8 vs. 49.3±20.1; p=0.001) only in the group of CAD subjects with type 2 diabetes mellitus. The protective effect of the AA genotype against severity of CAD was not observed in the non-diabetic group.

Conclusion: This result confirms that the –374AA genotype of the RAGE gene promoter is a protective factor against the severity of CAD lesions in type 2 diabetic patients.

Clin Chem Lab Med 2007;45:1268–72.

Keywords: advanced glycation end products; coronary artery disease; disease severity; Euro-Brazilians; risk factor; single nucleotide polymorphism; type 2 diabetes

About the article

Corresponding author: Geraldo Picheth, Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.O. Box 19046, 81531-990 Curitiba, PR, Brazil Phone/Fax: +55-41-3274-5593, ,

Received: 2007-01-12

Accepted: 2007-06-01

Published Online: 2007-10-10

Published in Print: 2007-10-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 10, Pages 1268–1272, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.273.

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