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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 45, Issue 11

Issues

Current state and future directions of neurochemical biomarkers for Alzheimer's disease

Daniëlle de Jong
  • 1Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Berry P.H. Kremer
  • 2Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcel G.M. Olde Rikkert
  • 3Alzheimer Center Nijmegen, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcel M. Verbeek
  • 4Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands, Alzheimer Center Nijmegen, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Center, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

In this comprehensive review, we summarize the current state-of-the-art of neurochemical biomarkers for Alzheimer's disease. Predominantly, these biomarkers comprise cerebrospinal fluid biomarkers directly related to the pathophysiology of this disorder (such as amyloid β protein, tau protein). We particularly pay attention to the innovations in this area that have been made in technological aspects during the past 5 years (e.g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid β oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma.

Clin Chem Lab Med 2007;45:1421–34.

Keywords: Alzheimer's disease; amyloid β protein; biological markers; cerebrospinal fluid; tau proteins

About the article

Corresponding author: Dr. M.M. Verbeek, PhD, MSc, Department of Neurology, 830 LKN, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 Nijmegen, The Netherlands Phone: +31-24-3614567, Fax: +31-24-3668754,


Received: 2007-06-07

Accepted: 2007-08-28

Published in Print: 2007-11-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 11, Pages 1421–1434, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.320.

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