Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 12

Issues

Hyperhomocysteinemia – association with renal transsulfuration and redox signaling in rats

Li Pin-Lan
  • 1Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yi Fan
  • 2Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Li Ningjun
  • 3Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-12-08 | DOI: https://doi.org/10.1515/CCLM.2007.344

Abstract

Despite substantial evidence indicating the association of hyperhomocysteinemia (hHcys) and end-stage renal disease (ESRD), the pathogenic role of increased plasma homocysteine (Hcys) levels in the progression of ESRD remains unclear. This review will briefly summarize recent findings regarding the role of hHcys in the development of glomerulosclerosis, the association of hHcys with reduced renal transsulfuration and Hcys-induced changes of redox signaling in the development of glomerulosclerosis in rat kidneys. Based on these results, it is concluded that hHcys is implicated in glomerular sclerosis in hypertension, elevated plasma Hcys in Dahl salt-sensitive (SS) hypertensive rats is due to downregulation of cystathionine β-synthase (CBS) expression and consequent abnormality of transsulfuration in the kidney compared with normotensive rats. Hcys-induced superoxide (O2 · –) production by activation of NADPH oxidase as a triggering mechanism contributes to the effects of Hcys on the homeostasis of extracellular matrix and consequent sclerosis in the glomeruli, and NADPH oxidase activation by Hcys is associated with enhanced Rac GTPase activity.

Clin Chem Lab Med 2007;45:1688–93.

Keywords: glomerular sclerosis; homocysteine; NADPH oxidase; Rac GTPase; superoxide

About the article

Corresponding author: Dr. Pin-Lan Li, Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298, USA Phone: +1-804-828-4793, Fax: +1-804-828-4794,


Received: 2007-07-12

Accepted: 2007-09-21

Published Online: 2007-12-08

Published in Print: 2007-12-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 12, Pages 1688–1693, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.344.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Katherine J. Jeppe, Melissa E. Carew, Vincent Pettigrove, and Ary A. Hoffmann
Environmental Toxicology and Chemistry, 2017, Volume 36, Number 3, Page 691
[2]
Cheng Wan, Hua Su, and Chun Zhang
Oxidative Medicine and Cellular Longevity, 2016, Volume 2016, Page 1
[4]
Young Chul Kim, Do Young Kwon, and Ji Hyun Kim
Amino Acids, 2014, Volume 46, Number 4, Page 963

Comments (0)

Please log in or register to comment.
Log in