Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 12 (Dec 2007)

Issues

Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis

Published Online: 2007-12-08 | DOI: https://doi.org/10.1515/CCLM.2007.346

Abstract

Background: Elevated plasma total homocysteine is a risk factor for cardiovascular disease (CVD), but the randomized trials of dietary supplementation with B-vitamins to lower homocysteine have not yet provided clear evidence of benefit on vascular risk.

Methods: Cumulative meta-analysis of all randomized trials assessing the effects of lowering homocysteine levels with B-vitamins on risk of CVD.

Results: An individual patient data meta-analysis of all randomized trials of the effects on vascular risk of lowering homocysteine with B-vitamins will maximize the power to assess the epidemiologically predicted differences in risk. Among the 12 randomized homocysteine-lowering trials for prevention of CVD, involving more than 1000 participants, data should be available on approximately 52,000 participants (32,000 with prior CVD in unfortified populations; and 14,000 with prior CVD and 6000 with renal disease in fortified populations). To minimize bias, the design and primary analyses to be carried out have been pre-specified. The analyses will include assessment of effects on major vascular events (MVE), stroke, major coronary events (MCE), in addition to venous thrombosis, cancer and fractures. Additional analyses will assess effects on vascular outcomes in sub-groups defined by population, prior disease, per 3 μmol/L difference in homocysteine levels achieved by treatment, pre-treatment vitamin status, duration, age, sex and vascular events excluding revascularizations and, separately, excluding vascular events occurring during the first year of treatment.

Conclusions: A cumulative meta-analysis of the homocysteine-lowering trials should ensure that reliable evidence emerges about the effects of lowering homocysteine on risk of vascular and non-vascular outcomes.

Clin Chem Lab Med 2007;45:1575–81.

Keywords: folic acid; homocysteine; meta-analysis; trials; vitamin B12

About the article

Corresponding author: Robert Clarke, Clinical Trial Service Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK Phone: +44-1865-743743, Fax: +44-1865-743985,


Received: 2007-06-21

Accepted: 2007-10-08

Published Online: 2007-12-08

Published in Print: 2007-12-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.346.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Wolfgang Herrmann
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 12
[2]
M. Ebbing, K. H. Bønaa, E. Arnesen, P. M. Ueland, J. E. Nordrehaug, K. Rasmussen, I. Njølstad, D. W. Nilsen, H. Refsum, A. Tverdal, S. E. Vollset, H. Schirmer, Ø. Bleie, T. Steigen, Ø. Midttun, Å. Fredriksen, E. R. Pedersen, and O. Nygård
Journal of Internal Medicine, 2010, Volume 268, Number 4, Page 367
[3]
Concepción Sánchez-Moreno, Antonio Jiménez-Escrig, and Antonio Martín
Nutrition Research Reviews, 2009, Volume 22, Number 01, Page 49

Comments (0)

Please log in or register to comment.
Log in