Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 12

Issues

The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases

Rima Obeid
  • 1Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg/Saar, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Andrew McCaddon / Wolfgang Herrmann
  • 3Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg/Saar, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-12-08 | DOI: https://doi.org/10.1515/CCLM.2007.356

Abstract

Hyperhomocysteinemia (HHcy) is related to central nervous system diseases. Epidemiological studies show a positive, dose-dependent relationship between plasma total homocysteine (tHcy) concentration and neurodegenerative disease risk. tHcy is a marker of B-vitamin (folate, B12, B6) status. Hypomethylation, caused by low B-vitamin status and HHcy, is linked to key pathomechanisms of dementia; B-vitamin supplementation could potentially reduce neurological damage. In retrospective studies, the association between tHcy and cognition is impressive; there is also evidence that tHcy-lowering treatment could be effective in primary and secondary stroke prevention. Increased tHcy and low serum folate occur in patients with Parkinson's disease, especially those receiving L-dopa. There is also an association between HHcy and multiple sclerosis, and between B-vitamin status and depression. Studies also confirm a causal role for tHcy in epilepsy, and certain anti-epileptics enhance HHcy. B-vitamin status should be optimized by ensuring sufficient intake in patients with neuropsychiatric diseases. HHcy occurs commonly in the elderly and can contribute to age-related neurodegeneration. Treatment with folic acid, B12 and B6 lowers tHcy. For secondary and primary prevention from several neuropsychiatric disorders, it seems prudent to actively identify deficient subjects and ensure sufficient vitamin intake.

Clin Chem Lab Med 2007;45:1590–606.

Keywords: brain atrophy; depression; epilepsy; homocysteine; neurodegeneration; vitamin B group

About the article

Corresponding author: Prof. Dr. Wolfgang Herrmann, Department of Clinical Chemistry and Laboratory Medicine, University Hospital of the Saarland, Kirrberger Straße, Gebäude 57, 66421 Homburg, Germany Phone: +49-6841-1630700, Fax: +49-6841-1630703,


Received: 2007-08-10

Accepted: 2007-10-25

Published Online: 2007-12-08

Published in Print: 2007-12-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 12, Pages 1590–1606, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.356.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Kelly Virecoulon Giudici, Philipe de Souto Barreto, Florent Guerville, John Beard, Islene Araujo de Carvalho, Sandrine Andrieu, Yves Rolland, and Bruno Vellas
Experimental Gerontology, 2019, Volume 127, Page 110716
[2]
Luciana Baroni, Chiara Bonetto, Gianluca Rizzo, Caterina Bertola, Livio Caberlotto, and Giorgio Bazzerla
Journal of Alzheimer's Disease, 2019, Volume 70, Number 2, Page 443
[3]
Domenico De Berardis, Luigi Olivieri, Gabriella Rapini, Serena Di Natale, Nicola Serroni, Michele Fornaro, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Federica Vellante, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Gianluca Serafini, Maurizio Pompili, Giovanni Martinotti, and Massimo Di Giannantonio
Clinical Psychopharmacology and Neuroscience, 2019, Volume 17, Number 2, Page 318
[4]
Stephen M. Stahl
CNS Spectrums, 2010, Volume 15, Number 4, Page 220
[5]
Andrea Annibal, Hannah Tam, Christian Latza, and Adam Antebi
Journal of Mass Spectrometry, 2019, Volume 54, Number 4, Page 316
[6]
Terry L. Wahls, Catherine A. Chenard, and Linda G. Snetselaar
Nutrients, 2019, Volume 11, Number 2, Page 352
[7]
N. Sanoj Rejinold, Hye Kyoung Kim, Abdel F. Isakovic, Deborah L. Gater, and Yeu-Chun Kim
Journal of Controlled Release, 2019, Volume 298, Page 83
[8]
Longfei Jia, Yaqiong Zeng, Yun Hu, Jie Liu, Chao Yin, Yingjie Niu, Chenfei Wang, Juan Li, Yimin Jia, Jian Hong, and Ruqian Zhao
Biology of Reproduction, 2018
[9]
Peng Zeng, Yan Shi, Xiao-Ming Wang, Li Lin, Yan-Jun Du, Na Tang, Qun Wang, Ying-Yan Fang, Jian-Zhi Wang, Xin-Wen Zhou, Youming Lu, and Qing Tian
International Journal of Neuropsychopharmacology, 2018
[10]
Dietmar Enko, Andreas Meinitzer, Wolfgang Brandmayr, Gabriele Halwachs-Baumann, Wolfgang J. Schnedl, Gernot Kriegshäuser, and Juan J Loor
PLOS ONE, 2018, Volume 13, Number 8, Page e0202567
[12]
Rupalika, Naorem Kiranmala Devi, Vipin Gupta, M.P. Sachdeva, Arun Kumar, and K.N. Saraswathy
Gene Reports, 2018
[13]
Matin Khosravi-Largani, Parmida Pourvali-Talatappeh, Ali Mohammad Rousta, Maedeh Karimi-Kivi, Elahe Noroozi, Ali Mahjoob, Yasaman Asaadi, Alireza Shahmohammadi, Sarina Sadeghi, Shiva Shakeri, Kimiya Ghiyasvand, and Masoumeh Tavakoli-Yaraki
eNeurologicalSci, 2018, Volume 10, Page 37
[14]
Nassila Akchiche, Carine Bossenmeyer-Pourié, Racha Kerek, Nicolas Martin, Grégory Pourié, Violette Koziel, Déborah Helle, Jean-Marc Alberto, Sandrine Ortiou, Jean-Michel Camadro, Thibaut Léger, Jean-Louis Guéant, and Jean-Luc Daval
The FASEB Journal, 2012, Volume 26, Number 10, Page 3980
[15]
Kaitlyn Rechenberg
Clinical Psychological Science, 2016, Volume 4, Number 1, Page 144
[16]
Ayesha Z. Sherzai, Michele Tagliati, Katherine Park, Shant Pezeshkian, and Dean Sherzai
Gerontology and Geriatric Medicine, 2016, Volume 2, Page 233372141664428
[17]
Efthimios Dardiotis, Stylianos Arseniou, Maria Sokratous, Zisis Tsouris, Vasileios Siokas, Alexios-Fotios A. Mentis, Amalia Michalopoulou, Athina Andravizou, Metaxia Dastamani, Konstantinos Paterakis, Dimitrios Bogdanos, and Alexandros Brotis
Multiple Sclerosis and Related Disorders, 2017, Volume 17, Page 190
[18]
Yu Shi, Dongdong Yang, Yanyan Zeng, and Wen Wu
Frontiers in Aging Neuroscience, 2017, Volume 9
[19]
Janaína Kolling, Aline Longoni, Cassiana Siebert, Tiago Marcon dos Santos, Eduardo Peil Marques, Jaqueline Carletti, Lenir Orlandi Pereira, and Angela T. S. Wyse
Neurotoxicity Research, 2017
[20]
Zuzana Bystrická, Lucia Laubertová, Monika Ďurfinová, and Zuzana Paduchová
Biomarkers, 2017, Page 1
[21]
Keren K. Griffiths and Richard J. Levy
Oxidative Medicine and Cellular Longevity, 2017, Volume 2017, Page 1
[22]
Ulfuara Shefa, Seung Geun Yeo, Min-Sik Kim, In Ok Song, Junyang Jung, Na Young Jeong, and Youngbuhm Huh
BioMed Research International, 2017, Volume 2017, Page 1
[23]
Vijay K. Sharma, Saroj K. Das, Priyanka Dhar, Kalpana B. Hota, Bidhu B. Mahapatra, Vivek Vashishtha, Ashish Kumar, Sunil K. Hota, Tsering Norboo, Ravi B. Srivastava, and Sonia Brucki
PLoS ONE, 2014, Volume 9, Number 7, Page e101448
[24]
Talal Jamil Qazi, Zhenzhen Quan, Asif Mir, and Hong Qing
Molecular Neurobiology, 2017
[25]
Sandesh Panthi, Hyung-Joo Chung, Junyang Jung, and Na Young Jeong
Oxidative Medicine and Cellular Longevity, 2016, Volume 2016, Page 1
[26]
Richard E. Frye, Manuel F. Casanova, S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, Gregory L. Brown, Stephen M. Edelson, John C. Slattery, and James B. Adams
Frontiers in Neuroscience, 2016, Volume 10
[27]
Ann-Chee Yap, Ummi Mahamad, Shen-Yang Lim, Hae-Jo Kim, and Yeun-Mun Choo
Sensors, 2014, Volume 14, Number 11, Page 21140
[28]
Andrew McCaddon and Joshua W. Miller
Nutrition Reviews, 2015, Volume 73, Number 10, Page 723
[29]
K. Kunisawa, N. Nakashima, M. Nagao, T. Nomura, S. Kinoshita, and M. Hiramatsu
Behavioural Brain Research, 2015, Volume 292, Page 36
[30]
Carmen Puig-Alcaraz, Milagros Fuentes-Albero, Jesús Calderón, Dolores Garrote, and Omar Cauli
Psychiatry Research, 2015, Volume 229, Number 3, Page 1031
[31]
Allen Mark Jacobs and Dunlei Cheng
Journal of Diabetes Mellitus, 2014, Volume 04, Number 03, Page 249
[32]
Allen Mark Jacobs and Dunlei Cheng
Journal of Diabetes Mellitus, 2013, Volume 03, Number 03, Page 134
[33]
Jean-Maurice Delabar, Alizée Latour, Christophe Noll, Marjorie Renon, Sacha Salameh, Jean-Louis Paul, Mariona Arbones, Jamileh Movassat, and Nathalie Janel
Molecular Genetics and Metabolism Reports, 2014, Volume 1, Page 487
[34]
Sohini Sengupta Neogi, Monica Thomas, Archna Sharma, Jaishree Kumar, and Uma Khanduri
Canadian Journal of Physiology and Pharmacology, 2014, Volume 92, Number 9, Page 713
[35]
Hai-Jun Wei, Xiang Li, and Xiao-Qing Tang
Journal of Clinical Neuroscience, 2014, Volume 21, Number 10, Page 1665
[36]
Chiara Briani, Chiara Torre, Valentina Citton, Renzo Manara, Sara Pompanin, Gianni Binotto, and Fausto Adami
Nutrients, 2013, Volume 5, Number 11, Page 4521
[37]
Evangelia Kararizou, George Paraskevas, Nikolaos Triantafyllou, George Koutsis, Maria E. Evangelopoulos, Dimitrios Mandellos, Constantinos Sfagos, and Elisabeth Kapaki
Journal of the Chinese Medical Association, 2013, Volume 76, Number 11, Page 611
[38]
P.K. Kamat, A. Kalani, S. Givvimani, P.B. Sathnur, S.C. Tyagi, and N. Tyagi
Neuroscience, 2013, Volume 252, Page 302
[39]
Jun Wang, Jin-Tai Yu, Meng-Shan Tan, Teng Jiang, and Lan Tan
Ageing Research Reviews, 2013, Volume 12, Number 4, Page 1024
[40]
Karin Nilsson, Lars Gustafson, and Björn Hultberg
Dementia and Geriatric Cognitive Disorders, 2012, Volume 34, Number 2, Page 121
[41]
Alessandro Viggiano, Emanuela Viggiano, Marcellino Monda, Diego Ingrosso, Alessandra F. Perna, and Bruno De Luca
Brain Research, 2012, Volume 1471, Page 66
[42]
Sabine Pompéia, Bruno H.C. Grego, Marcia Pradella-Hallinan, Helena Hachul, Sergio Tufik, and Vânia D'Almeida
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009, Volume 33, Number 6, Page 933
[43]
Aline A. da Cunha, Ana Paula Horn, Juliana B. Hoppe, Patrícia B. Grudzinski, Samanta O. Loureiro, Andréa G.K. Ferreira, Maira J. da Cunha, Felipe Schmitz, Christianne G. Salbego, and Angela T.S. Wyse
International Journal of Developmental Neuroscience, 2012, Volume 30, Number 5, Page 369
[44]
Michael Pirchl, Celine Ullrich, Barbara Sperner-Unterweger, and Christian Humpel
Molecular and Cellular Neuroscience, 2012, Volume 49, Number 4, Page 456
[45]
Maira J. da Cunha, Aline A. da Cunha, Andréa G.K. Ferreira, Fernanda R. Machado, Felipe Schmitz, Daniela D. Lima, Debora Delwing, Ben Hur M. Mussulini, Susana Wofchuk, Carlos A. Netto, and Angela T.S. Wyse
International Journal of Developmental Neuroscience, 2012, Volume 30, Number 2, Page 69
[46]
Anna Bochyńska, Wanda Lipczyńska-Łojkowska, Magdalena Gugała-Iwaniuk, Waldemar Lechowicz, Magdalena Restel, Ałła Graban, Beata Lipska, and Danuta Ryglewicz
Seizure, 2012, Volume 21, Number 4, Page 276
[47]
Cristiane Matté, Ben Hur M. Mussulini, Tiago M. dos Santos, Flávia M.S. Soares, Fabrício Simão, Aline Matté, Diogo L. de Oliveira, Christianne G. Salbego, Susana T. Wofchuk, and Angela T.S. Wyse
International Journal of Developmental Neuroscience, 2010, Volume 28, Number 2, Page 183
[48]
L. Jaworska-Feil, D. Jantas, M. Leskiewicz, B. Budziszewska, M. Kubera, A. Basta-Kaim, A.W. Lipkowski, and W. Lason
Neuropeptides, 2010, Volume 44, Number 6, Page 495
[49]
Jean Woo
Medical Clinics of North America, 2011, Volume 95, Number 3, Page 477
[50]
Aline A. da Cunha, Andréa G. K. Ferreira, Maira J. da Cunha, Carolina D. Pederzolli, Débora L. Becker, Juliana G. Coelho, Carlos S. Dutra-Filho, and Angela T. S. Wyse
Molecular and Cellular Biochemistry, 2011, Volume 358, Number 1-2, Page 153
[51]
Guixiang Zhao, Earl S Ford, Chaoyang Li, Kurt J Greenlund, Janet B Croft, and Lina S Balluz
Nutrition Journal, 2011, Volume 10, Number 1
[52]
[53]
Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D. Coleman, and Joseph Rogers
Neurobiology of Aging, 2011, Volume 32, Number 7, Page 1161
[54]
Karin Nilsson, Lars Gustafson, and Björn Hultberg
International Journal of Geriatric Psychiatry, 2011, Page n/a
[55]
Amira Hamzaoui, Olfa Harzallah, Rim Klii, and Silvia Mahjoub
Biochemistry Research International, 2010, Volume 2010, Page 1
[56]
Wolfgang Herrmann and Rima Obeid
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 3
[57]
Wolfgang Herrmann
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 12
[58]
Wolfgang Herrmann, Rima Obeid, Heike Schorr, Ulrich Hübner, Jürgen Geisel, Marga Sand-Hill, Nayyar Ali, and Markus Herrmann
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 11
[59]
Michael Pirchl, Celine Ullrich, and Christian Humpel
European Journal of Neuroscience, 2010, Volume 32, Number 9, Page 1516
[60]
Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Wakaba Fukushima, Chikako Kiyohara, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, and Masaki Nagai
British Journal of Nutrition, 2010, Volume 104, Number 05, Page 757
[61]
Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T. Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H. Marti, and Johannes Schenkel
Journal of Molecular Neuroscience, 2010, Volume 41, Number 1, Page 74
[62]
Shuntaro Ikeda, Takahiro Namekawa, Miki Sugimoto, and Shin-ichi Kume
Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 2010, Volume 9999A, Page n/a
[63]
Edmund D. Hong, Warren D. Taylor, Douglas R. McQuoid, Guy G. Potter, Martha E. Payne, Allison Ashley-Koch, and David C. Steffens
The American Journal of Geriatric Psychiatry, 2009, Volume 17, Number 10, Page 847
[64]
Theresa A. Zesiewicz and Marian L. Evatt
CNS Drugs, 2009, Volume 23, Number 10, Page 817
[65]
Conny Nordin and Ingemar Sjödin
International Journal of Mental Health and Addiction, 2009, Volume 7, Number 1, Page 168

Comments (0)

Please log in or register to comment.
Log in