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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 2

Issues

Lipid transfer protein activities in subjects with impaired glucose tolerance

Ulrich Julius / Matti Jauhiainen / Christian Ehnholm / Jens Pietzsch
  • Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany
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Published Online: 2007-02-20 | DOI: https://doi.org/10.1515/CCLM.2007.032

Abstract

Background: Impaired glucose tolerance (IGT) is associated with an increased risk of atherosclerosis that may be due in part to dyslipidemia. The purpose of this study was to assess the regulatory role of lipid transfer proteins in the development of this dyslipidemia.

Methods: Activities of cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP), as well as lipid and protein components of the major lipoprotein fractions, were evaluated in probands with IGT and were compared with those in subjects with normal glucose tolerance. The effect of a fat-rich meal on these variables was also investigated.

Results: IGT probands had a higher triglyceride content in subfractions of low- (LDL) and high-density lipoprotein (HDL). IGT patients had higher fasting CETP activity. The latter was positively correlated with HDL2 triglycerides and negatively with HDL3 total cholesterol. PLTP activity and mass were not higher in IGT patients. However, PLTP activity correlated with components of VLDL and LDL and was influenced by the type of obesity. Neither CETP and PLTP activities nor PLTP mass were altered by a fat-rich meal. PLTP and CETP activities correlated in both fasting and postprandial conditions.

Conclusions: Increased fasting CETP activity may contribute to increased risk of atherosclerosis in subjects with IGT.

Clin Chem Lab Med 2007;45:237–43.

Keywords: cholesterol ester transfer protein; impaired glucose tolerance; oral fat loading test; oral glucose tolerance test; phospholipid transfer protein

About the article

Corresponding author: Prof. Dr. Ulrich Julius, Medizinische Klinik und Poliklinik III, Universitätsklinikum Dresden, Fetscherstr. 74, 01307 Dresden, Germany Phone: +49-351-4582306, Fax: +49-351-4585306,


Received: September 10, 2006

Accepted: October 30, 2006

Published Online: 2007-02-20

Published in Print: 2007-02-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 2, Pages 237–243, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.032.

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