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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 45, Issue 2 (Feb 2007)

Issues

Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis

Mudit Vaid
  • Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Delhi, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Savneet Kaur
  • Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Delhi, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Helen Sambatakou
  • School of Medicine, The Manchester University, Wythenshawe Hospital, Manchester, UK and Present address: University of Athens, Athens, Greece
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Taruna Madan
  • Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Delhi, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ David W. Denning / P. Usha Sarma
  • Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Delhi, India and Present address: Department of Plant Pathology, Indian Agricultural Research Institute, Delhi, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-02-20 | DOI: https://doi.org/10.1515/CCLM.2007.033

Abstract

Background: Distinct host immune status predisposes to different forms of pulmonary aspergillosis.

Methods: Patients with chronic cavitary pulmonary aspergillosis (CCPA; n=15) or allergic bronchopulmonary aspergillosis (ABPA; n=7) of Caucasian origin were screened for single nucleotide polymorphisms (SNPs) in the collagen region of surfactant proteins A1 (SP-A1) and A2 (SP-A2) and mannose binding lectin (MBL).

Results: The T allele at T1492C and G allele at G1649C of SP-A2 were observed at slightly higher frequencies in ABPA patients (86% and 93%) than in controls (63% and 83%), and the C alleles at position 1492 and 1649 were found in higher frequencies in CCPA patients (33% and 25%) than in ABPA patients (14% and 7%) (all p>0.05). However, the CC genotype at position 1649 of SP-A2 was significantly associated with CCPA (χ2=7.94; pcorr≤0.05). Similarly, ABPA patients showed a higher frequency of the TT genotype (71%) at 1492 of SP-A2 than controls (43%) and CCPA patients (41%) (p>0.05). In the case of MBL, the T allele (OR=3.1, range 1.2–8.9; p≤0.02) and CT genotype (χ2=6.54; pcorr≤0.05) at position 868 (codon 52) were significantly associated with CCPA, but not with ABPA. Further analysis of genotype combinations at position 1649 of SP-A2 and at 868 of MBL between patient groups showed that both CC/CC and CC/CT SP-A2/MBL were found only in CCPA patients, while GG/CT SP-A2/MBL was significantly higher in CCPA patients in comparison to ABPA patients (p≤0.05). SNPs analysed in SP-A1 did not differ between cases and controls.

Conclusions: Distinct alleles, genotypes and genotype combinations of SP-A2 and MBL may contribute to differential susceptibility of the host to CCPA or ABPA.

Clin Chem Lab Med 2007;45:183–6.

Keywords: allergic bronchopulmonary aspergillosis; Aspergillus fumigatus; chronic cavitary pulmonary aspergillosis; mannose-binding lectin; surfactant protein A

About the article

Corresponding author: Professor David W. Denning, Education and Research Centre, Wythenshawe Hospital, Southmoor Rd, Manchester M23 9LT, UK Phone: +44-161-2915811, Fax: +44-161-2915806,


Received: September 3, 2006

Accepted: November 10, 2006

Published Online: 2007-02-20

Published in Print: 2007-02-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.033.

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