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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

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Source Normalized Impact per Paper (SNIP) 2017: 1.188

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1437-4331
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Volume 45, Issue 2

Issues

Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men

Seija Eskelinen
  • Department of Family Medicine, University of Turku, Turku, Finland and Pori Health Center, Pori, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tero Vahlberg / Raimo Isoaho
  • Department of Family Medicine, University of Turku, Turku, Finland, Pori Health Center, Pori, Finland and Härkätie Health Center, Lieto, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sirkka-Liisa Kivelä
  • Department of Family Medicine, University of Turku, Turku, Finland, Unit of Family Medicine, Turku University Central Hospital, Turku, Finland and Satakunta Central Hospital, Pori, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kerttu Irjala
  • Clinical Chemistry, Turku University Hospital, Turku, Finland and Mehiläinen Oy, Turku, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

Background: Our aim was to establish sex hormone reference intervals measured with a new AutoDelfia immunoassay method for aged men free of medication and/or conditions known to influence sex hormone levels.

Methods: The reference population consisted of 466 individuals between 64 and 97 years (mean 72 years) and a mean body mass index (BMI) of 26.9 kg/m2.

Results and conclusions: Because age correlated significantly with most sex hormones studied, we calculated reference intervals for three age groups (64–69, 70–74 and ≥75 years). In clinical practice, single ranges can be used for men aged 64 years or over for testosterone, estradiol and follicle-stimulating hormone (FSH) with the AutoDelfia method. For free testosterone and luteinizing hormone (LH), separate reference intervals should be used for men aged 64–74 years and those aged 75 years or over. For sex hormone-binding globulin, two separate reference intervals by age (64–69 and ≥70 years) are also needed for aged men. LH and FSH reference ranges should be judged with caution, because they may be too high due to cases of subclinical hypogonadism included in the reference population.

Clin Chem Lab Med 2007;45:249–53.

Keywords: androgens; elderly; estrogens; men; reference interval; sex hormone-binding globulin

About the article

Corresponding author: Seija Eskelinen, Department of Family Medicine, Lemminkäisenkatu 1, University of Turku, 20014 Turku, Finland Phone: +358-400722725,


Received: March 29, 2006

Accepted: November 3, 2006

Published in Print: 2007-02-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 2, Pages 249–253, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.042.

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