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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


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1437-4331
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Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily

Giuseppe Stella1 / Rosario Sebastiano Spada2 / Santa Calabrese3 / Paolo Bosco4 / Guido Anello5 / Rosa-Maria Guéant-Rodriguez6 / Antonino Romano7 / Lahoucine Benamghar8 / Caterina Proto9 / Antonino Castellano10 / Adrian Fajardo11 / Lina Lipari12 / Salvatore Sirna13 / Jean-Louis Guéant14

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Corresponding author: Rosario Sebastiano Spada, MD, Geriatric Unit, IRCCS “Oasi” Institute for Research on Mental Retardation and Brain Aging Via Conte Ruggero, 73 94018 Troina (EN), Italy Phone: +39-0935-653966, Fax: +39-0935-936694,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 2, Pages 143–147, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2007.066, February 2007

Publication History

Received:
October 15, 2006
Accepted:
December 15, 2006

Abstract

Background: Association of thyroid dysfunction with plasma homocysteine levels and vitamin B12 has previously been reported. We evaluated these associations in the elderly in San Teodoro, a mountainous village of Sicily.

Methods: Subjects (n=279) aged 60–85 years (119 males and 160 females) were examined using self-reported signs, clinical examination and laboratory tests.

Results: Hypothyroidism and/or goiter were two characteristics that were not associated with a significant change in homocysteine when compared with euthyroidism and the absence of goiter. Vitamin B12 was significantly higher in subjects in the first quartile of the thyroid-stimulating hormone distribution, compared with those in the fourth quartile (371±207 vs. 297±196 pmol/L, p=0.0121). Homocysteine was significantly higher in the first quartile of the free tri-iodothyronine distribution compared to the third quartile (18.0±5.7 vs. 16.0±6.2 μmol/L, p=0.0130) and was correlated with log tri-iodothyronine in euthyroid subjects (p=0.0254). In multivariate analysis, homocysteine was associated with vitamin B12 (p=0.0014), folate (p<0.0001), creatinine (p<0.0001) and age (p<0.0001), but not with either free tri-iodothyronine (p=0.7680), tetra-iodothyronine (p=0.5706) or thyroid-stimulating hormone (p=0.2294).

Conclusions: Our results suggest that the influence of thyroid hormones on homocysteine is much weaker in elderly subjects than in selected patients with hypothyroidism.

Clin Chem Lab Med 2007;45:143–7.

Keywords: folate; homocysteine; thyroid dysfunction; vitamin B12

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[2]
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