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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 3

Issues

Secretory phospholipase A2 activity and release kinetics of vascular tissue remodelling biomarkers after coronary artery bypass grafting with and without cardiopulmonary bypass

Shaida Varnous
  • Département de Chirurgie thoracique et cardiovasculaire, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Said Ben Ayed
  • Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Joëlle Masliah
  • Service de Biochimie B, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pascal Leprince
  • Département de Chirurgie thoracique et cardiovasculaire, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Iradj Gandjbakhch
  • Département de Chirurgie thoracique et cardiovasculaire, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maguy Bernard
  • Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jean-Louis Beaudeux
  • Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-03-22 | DOI: https://doi.org/10.1515/CCLM.2007.060

Abstract

Background: Cardiopulmonary bypass (CPB) has long been recognised as a main cause of a postoperative complex systemic inflammatory response after coronary artery bypass grafting (CABG).

Methods: We determined the kinetics of peripheral blood release of the novel inflammatory biomarkers secretory phospholipase A2 (sPLA2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) during the first 6 days following surgery in 16 patients undergoing CABG with (on-pump, n=9) or without (off-pump, n=7) CPB. Kinetic curves for these markers were compared to those of the well-known inflammatory parameters C-reactive protein (CRP) and fibrinogen.

Results: sPLA2 activity exhibited a maximum value on day 2, then decreased until day 6 for both groups and in a similar manner as CRP levels. On the other hand, elevation of plasma levels of both MMP-9 and TIMP-1 occurred as early as on day 1 and remained at this level until day 6. No significant difference in kinetic characteristics (peak value, area under the curve, initial slope) between CABG with and without CPB was observed.

Conclusions: These data show that the off- and on-pump groups did not show significantly different kinetics for the releases of all biomarkers studied, including sPLA2 and biomarkers of the MMP-TIMP network. The off-pump procedure may therefore lead to global surgical trauma as important as CPB in terms of the systemic inflammatory process and matrix proteolysis pathway activation.

Clin Chem Lab Med 2007;45:372–5.

Keywords: cardiopulmonary bypass; coronary artery bypass grafting; inflammation; matrix metalloproteinases; phospholipase A2

About the article

Corresponding author: Jean-Louis Beaudeux, Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47-83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France Phone: +33-1-42162187, Fax: +33-1-42162175,


Received: September 19, 2006

Accepted: December 6, 2006

Published Online: 2007-03-22

Published in Print: 2007-03-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 3, Pages 372–375, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.060.

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