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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 3

Issues

Multicentre physiological reference intervals for serum concentrations of immunoglobulins A, G and M, complement C3c and C4 measured with Tina-Quant® reagents systems

Xavier Fuentes-Arderiu
  • Laboratori Clínic, IDIBELL—Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Catalonia, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eduardo Alonso-Gregorio / Virtudes Álvarez-Funes / Carmen Ambrós-Marigómez / Lluís Coca-Fábregas / Marta Cruz-Placer / Julián Díaz-Fernández / María Pilar Pinel-Julián / Beatriz Gutiérrez-Cecchini / Pilar Herrero-Bernal / Marcos Sempere-Alcocer / Francisca García-Caballero / María del Mar Larrea-Ortiz-Quintana
  • Laboratorio de Análisis Clínicos, Hospital Santiago Apóstol, Miranda de Ebro, Castille-León, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pedro La-Torre-Marcellán
  • Laboratorio de Análisis Clínicos, Centro Médico de Especialidades Ramón y Cajal, Zaragoza, Aragon, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ María del Señor López-Vélez / Carmen Mar-Medina / Javier Martín-Oncina / María Victoria Rodríguez-Hernández / María Victoria Romero-Sotomayor / Cándido Serrano-López
  • Laboratorio de Análisis Clínicos, Complejo Hospitalalario, Albacete, Castile-La Mancha, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Adolfo Sicilia-Enríquez-de-Salamanca / Ana María Velasco-Romero
  • Laboratorio de Análisis Clínicos, Hospital La Mancha Centro, Alcázar de San Juan, Castile-La Mancha, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Santiago Juvé-Cuxart

Abstract

Background: Clinical laboratories seeking accreditation for compliance with ISO 15189:2003 need to demonstrate that the physiological reference intervals communicated to all users of the laboratory service are appropriate for the patient population served and for the measurement systems used. In the case of immunological quantities, few articles have been published in peer-reviewed journals.

Methods: A total of 21 clinical laboratories in different regions of Spain collaborated in identifying reference individuals and determining adult reference intervals for some immunological quantities measured using RD/Hitachi Modular Analytics analysers and Tina-Quant® reagent systems. These immunological quantities are the mass concentrations of immunoglobulin A, immunoglobulin G, immunoglobulin M, complement C3c and complement C4 in serum. All the logistic work was carried out in co-operation with the supplier of the reagents and analysers (Roche Diagnostics España, S.L., Sant Cugat del Vallès, Catalonia, Spain). From the set of reference values obtained by each laboratory, multicentre reference limits were estimated non-parametrically.

Results and conclusions: The reference intervals estimated in this study for concentrations of serum components under consideration are: complement C3c, 0,62–1,64 g/L for women and men; complement C4, 0,14–0,72 g/L for women and men; immunoglobulin A, 0,89–4,80 g/L for women and men; immunoglobulin G, 6,5–14,3 g/L for women and men; and immunoglobulin M, 0,48–3,38 g/L for women and 0,41–2,46 g/L for men. (According to ISO, IUPAC and IFCC recommendations, the comma is used as the decimal sign.)

Clin Chem Lab Med 2007;45:387–90.

Keywords: complement C3c; complement C4; immunoglobulin A; immunoglobulin G; immunoglobulin M; multicentre reference values; physiological reference intervals

About the article

Corresponding author: Xavier Fuentes-Arderiu, Laboratori Clínic, IDIBELL—Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 l'Hospitalet de Llobregat, Catalonia, Spain Fax: +34-93-2607546,


Received: October 30 , 2006

Accepted: December 15, 2006

Published in Print: 2007-03-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 3, Pages 387–390, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.069.

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