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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review

David Gable1 / Saskia C. Sanderson2 / Steve E. Humphries3




Corresponding author: Steve E. Humphries, Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free & University College London Medical School, 5 University Street, London WC1E 6JF, UK Phone: +44-207-6796962, Fax: +44-107-6796212,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 3, Pages 301–308, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2007.070, March 2007

Publication History

September 27, 2006
December 14, 2006


The current worldwide prevalence of type 2 diabetes (T2D) was estimated to be 2.8% in 2000, but it is predicted to increase to epidemic proportions in the coming decades, primarily due to lifestyle changes, particularly obesity. In the United Kingdom there are over 1.4 million men and women with T2D. In addition to a strong environmental element, the existence of an underlying genetic component to T2D risk is supported by twin studies, family studies and the widely different T2D prevalence across ethnic groups. Here we review data showing that several common genetic risk variants for T2D have now been successfully identified, with modest, but meta-analytical robust effects on risk (in the region of 1.1–1.5-fold risk per allele). Use of these in combination may have clinical utility in identifying subjects at high risk. Whether this information will be motivating to make the type of lifestyle changes that have been shown to reduce the rate of progression from the pre-diabetes state to overt T2D is discussed.

Clin Chem Lab Med 2007;45:301–8.

Keywords: genetic testing; motivation; obesity; type 2 diabetes

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