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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 45, Issue 3 (Mar 2007)

Issues

How to comprehensively analyse proteins and how this influences nutritional research

Martin Kussmann
  • BioAnalytical Science Department, Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland

Abstract

Proteomics, the comprehensive analysis of a protein complement in a cell, tissue or biological fluid at a given time, is a key platform within the “omic” technologies that also encompass genomics (gene analysis), transcriptomics (gene expression analysis) and metabolomics (metabolite profiling). This review summarises protein pre-separation, identification, quantification and modification/interaction analysis and puts them into perspective for nutritional R&D. Mass spectrometry has progressed with regard to mass accuracy, resolution and protein identification performance. Separation, depletion and enrichment techniques can increasingly cope with complexity and dynamic range of proteomic samples. Hence, proteomic studies currently provide a broader, albeit still incomplete, coverage of a given proteome. Proteomics adapted and applied to nutrition and health should demonstrate ingredient efficacy, deliver biomarkers for health and disease disposition, help in differentiating dietary responders from non-responders, and discover bioactive food components.

Clin Chem Lab Med 2007;45:288–300.

Keywords: biomarker; health; mass spectrometry; nutrition; proteomics

References

  • 1.

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  • 4.

  • 5.

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  • 7.

  • 8.

  • 9.

  • 10.

  • 11.

  • 12.

  • 13.

  • 14.

  • 15.

  • 16.

  • 17.

  • 18.

  • 19.

  • 20.

  • 21.

  • 22.

  • 23.

  • 24.

  • 25.

  • 26.

  • 27.

  • 28.

  • 29.

  • 30.

  • 31.

  • 32.

  • 33.

  • 34.

  • 35.

  • 36.

  • 37.

  • 38.

  • 39.

  • 40.

  • 41.

  • 42.

  • 43.

  • 44.

  • 45.

  • 46.

  • 47.

  • 48.

  • 49.

  • 50.

  • 51.

  • 52.

  • 53.

  • 54.

  • 55.

  • 56.

  • 57.

  • 58.

  • 59.

  • 60.

  • 61.

  • 62.

  • 63.

  • 64.

  • 65.

  • 66.

  • 67.

  • 68.

  • 69.

  • 70.

  • 71.

  • 72.

  • 73.

  • 74.

  • 75.

  • 76.

  • 77.

  • 78.

  • 79.

  • 80.

  • 81.

  • 82.

  • 83.

  • 84.

  • 85.

  • 86.

  • 87.

  • 88.

  • 89.

  • 90.

  • 91.

  • 92.

  • 93.

  • 94.

  • 95.

  • 96.

  • 97.

  • 98.

  • 99.

  • 100.

  • 101.

  • 102.

  • 103.

  • 104.

  • 105.

  • 106.

  • 107.

  • 108.

  • 109.

  • 110.

  • 111.

  • 112.

  • 113.

  • 114.

  • 115.

  • 116.

  • 117.

  • 118.

  • 119.

  • 120.

  • 121.

  • 122.

  • 123.

  • 124.

  • 125.

  • 126.

  • 127.

  • 128.

  • 129.

  • 130.

  • 131.

  • 132.

  • 133.

  • 134.

  • 135.

  • 136.

  • 137.

  • 138.

  • 139.

  • 140.

  • 141.

  • 142.

  • 143.

  • 144.

  • 145.

  • 146.

  • 147.

  • 148.

  • 149.

  • 150.

  • 151.

  • 152.

  • 153.

  • 154.

  • 155.

  • 156.

  • 157.

  • 158.

  • 159.

  • 160.

  • 161.

  • 162.

About the article

Corresponding author: Martin Kussmann, BioAnalytical Science Department, Nestlé Research Centre, Nestec Ltd., Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland Phone: +41-21-7859572, Fax: +41-21-7859486


Received: October 9, 2006

Accepted: December 15, 2006

Published in Print: 2007-03-01



Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.071. Export Citation

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