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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

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Volume 45, Issue 3


Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond

Catherine Gallou-Kabani
  • Inserm, AP-HP, Université Paris-Descartes, Faculté de Médecine, Hôpital Necker-Enfants Malades, Inserm U781, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alexandre Vigé
  • Inserm, AP-HP, Université Paris-Descartes, Faculté de Médecine, Hôpital Necker-Enfants Malades, Inserm U781, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marie-Sylvie Gross
  • Inserm, AP-HP, Université Paris-Descartes, Faculté de Médecine, Hôpital Necker-Enfants Malades, Inserm U781, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Claudine Junien
  • Inserm, AP-HP, Université Paris-Descartes, Faculté de Médecine, Hôpital Necker-Enfants Malades, Inserm U781, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar


The phenotype of an individual is the result of complex interactions between genotype, epigenome and current, past and ancestral environment, leading to lifelong remodelling of our epigenomes. Various replication-dependent and -independent epigenetic mechanisms are involved in developmental programming, lifelong stochastic and environmental deteriorations, circadian deteriorations, and transgenerational effects. Several types of sequences can be targets of a host of environmental factors and can be associated with specific epigenetic signatures and patterns of gene expression. Depending on the nature and intensity of the insult, the critical spatiotemporal windows and developmental or lifelong processes involved, these epigenetic alterations can lead to permanent changes in tissue and organ structure and function, or to reversible changes using appropriate epigenetic tools. Given several encouraging trials, prevention and therapy of age- and lifestyle-related diseases by individualised tailoring of optimal epigenetic diets or drugs are conceivable. However, these interventions will require intense efforts to unravel the complexity of these epigenetic, genetic and environment interactions and to evaluate their potential reversibility with minimal side effects.

Clin Chem Lab Med 2007;45:321–7.

Keywords: environment; epigenetics; fetal programming; metabolic syndrome; nutrition; transgenerational effects


About the article

Corresponding author: Claudine Junien, Inserm Unit 781, Clinique Maurice Lamy, porte 15, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris, France Phone: +33-1-44494479, Fax: +33-1-47833206,

Received: November 6, 2006

Accepted: December 15, 2006

Published in Print: 2007-03-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 3, Pages 321–327, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.081.

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