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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

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ISSN
1437-4331
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In This Section
Volume 45, Issue 4 (Apr 2007)

Issues

Percutaneous coronary intervention-induced variations in systemic parameters of inflammation: relationship with the mode of stenting

Camille Brasselet
  • 1Département de Cardiologie, Hôpital Robert Debré, Reims, France and The first two authors contributed equally to the work.
/ Roselyne Garnotel
  • 2Laboratoire de Biologie et de Recherche Pédiatriques, American Memorial Hospital, Reims, France
/ Sophie Pérotin
  • 3Département de Cardiologie, Hôpital Robert Debré, Reims, France
/ Fabien Vitry
  • 4Unité d'Aide Méthodologique, Hôpital Maison Blanche, Reims, France
/ Jacques Elaerts
  • 5Département de Cardiologie, Hôpital Robert Debré, Reims, France
/ Antoine Lafont
  • 6Service de Cardiologie, Hôpital Européen Georges Pompidou, Paris, France
/ Damien Metz
  • 7Département de Cardiologie, Hôpital Robert Debré, Reims, France
/ Philippe Gillery
  • 8Laboratoire de Biologie et de Recherche Pédiatriques, American Memorial Hospital, Reims, France
Published Online: 2007-04-17 | DOI: https://doi.org/10.1515/CCLM.2007.088

Abstract

Background: During percutaneous coronary intervention, the technique of stent implantation (both direct and complementary stenting) is guided using both clinical and angiographic features. We assessed potential relationships between procedural parameters and angioplasty-induced variations in inflammatory parameters in patients treated by these two different techniques.

Methods: A total of 85 consecutive patients due to undergo stent implantation were prospectively enrolled. Inflammation was assessed in terms of C-reactive protein, fibrinogen, erythrocyte sedimentation rate and leukocyte count in samples taken before and 24 h after angioplasty. Patients were classified based on whether they underwent complementary (n=47) or direct stenting (n=38).

Results: Inflammation after complementary stenting was related to the duration of inflation (r=0.59; p<0.001), whereas inflammation after direct stenting was related to the inflation pressure (r=0.61; p=0.007), as assessed by C-reactive protein variation. None of the other parameters influenced the inflammatory response.

Conclusions: The inflammatory response after stent implantation depends on the mode of stenting. We therefore hypothesize that the inflammatory response after stenting might be related to the histological composition of the atherosclerotic plaques involved.

Clin Chem Lab Med 2007;45:526–30.

Keywords: coronary artery disease; C-reactive protein; inflammation; percutaneous coronary intervention; stent

About the article

Corresponding author: Dr. Camille Brasselet, MD, PhD, Département de cardiologie, Hôpital Robert Debré, 51092 Reims cedex, France Phone: +33-3-26787148, Fax: +33-3-26784132,


Received: 2006-10-09

Accepted: 2006-12-22

Published Online: 2007-04-17

Published in Print: 2007-04-01



Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: https://doi.org/10.1515/CCLM.2007.088. Export Citation

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