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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 45, Issue 5


Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome

Jana Vrbikova / Katerina Dvorakova / Tereza Grimmichova / Martin Hill / Sona Stanicka / David Cibula
  • 6Department of Obstetrics and Gynaecology, Charles University, 1st Medical Faculty, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bela Bendlova / Luboslav Starka / Karel Vondra
Published Online: 2007-05-07 | DOI: https://doi.org/10.1515/CCLM.2007.113


Background: Diabetes mellitus type 2 (DM2) affects 10% of women with polycystic ovary syndrome (PCOS). We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2.

Methods: Women with PCOS [n=244, age 27.4±7.5 years, body mass index (BMI) 27.5±6.9 kg/m2] and healthy women (n=57, age 26.8±5.8 years, BMI 21.3±2.1 kg/m2) underwent basal blood sampling and an oral glucose tolerance test (oGTT).

Results: Insulin resistance was identified in 40.2% of PCOS women. Impaired fasting glucose (5.6–6.9  mmol/L) was found in 30 subjects (12.3%), but the oGTT revealed IGT in only six of these cases and DM2 in one subject. IGT was found in 23 (9.4%) and DM2 in four (1.6%) of the women with PCOS. The conventional upper limits for total cholesterol, triglycerides, systolic and diastolic blood pressure and fasting glucose revealed low sensitivity for the identification of impaired glucose metabolism.

Conclusions: No single parameter nor any combination of them showed an accuracy sufficient for screening of IGT or DM2 in PCOS patients. All PCOS patients should be screened using an oGTT to identify disturbances in glucose metabolism.

Clin Chem Lab Med 2007;45:639–44.

Keywords: diabetes mellitus type 2; homeostatic model assessment of insulin resistance (HOMA-IR); impaired glucose tolerance; polycystic ovary syndrome

About the article

Corresponding author: Jana Vrbikova, MD, PhD, Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic Phone: +420-224-905111, Fax: +420-224-905325,

Received: 2006-11-29

Accepted: 2007-01-29

Published Online: 2007-05-07

Published in Print: 2007-05-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 5, Pages 639–644, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: https://doi.org/10.1515/CCLM.2007.113.

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