Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 5

Issues

Prevalence of insulin resistance and prediction of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome

Jana Vrbikova / Katerina Dvorakova / Tereza Grimmichova / Martin Hill / Sona Stanicka / David Cibula
  • 6Department of Obstetrics and Gynaecology, Charles University, 1st Medical Faculty, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bela Bendlova / Luboslav Starka / Karel Vondra
Published Online: 2007-05-07 | DOI: https://doi.org/10.1515/CCLM.2007.113

Abstract

Background: Diabetes mellitus type 2 (DM2) affects 10% of women with polycystic ovary syndrome (PCOS). We evaluated the sensitivity and specificity of clinical and fasting biochemical parameters in screening for impaired glucose tolerance (IGT) and DM2.

Methods: Women with PCOS [n=244, age 27.4±7.5 years, body mass index (BMI) 27.5±6.9 kg/m2] and healthy women (n=57, age 26.8±5.8 years, BMI 21.3±2.1 kg/m2) underwent basal blood sampling and an oral glucose tolerance test (oGTT).

Results: Insulin resistance was identified in 40.2% of PCOS women. Impaired fasting glucose (5.6–6.9  mmol/L) was found in 30 subjects (12.3%), but the oGTT revealed IGT in only six of these cases and DM2 in one subject. IGT was found in 23 (9.4%) and DM2 in four (1.6%) of the women with PCOS. The conventional upper limits for total cholesterol, triglycerides, systolic and diastolic blood pressure and fasting glucose revealed low sensitivity for the identification of impaired glucose metabolism.

Conclusions: No single parameter nor any combination of them showed an accuracy sufficient for screening of IGT or DM2 in PCOS patients. All PCOS patients should be screened using an oGTT to identify disturbances in glucose metabolism.

Clin Chem Lab Med 2007;45:639–44.

Keywords: diabetes mellitus type 2; homeostatic model assessment of insulin resistance (HOMA-IR); impaired glucose tolerance; polycystic ovary syndrome

About the article

Corresponding author: Jana Vrbikova, MD, PhD, Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic Phone: +420-224-905111, Fax: +420-224-905325,


Received: 2006-11-29

Accepted: 2007-01-29

Published Online: 2007-05-07

Published in Print: 2007-05-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 5, Pages 639–644, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: https://doi.org/10.1515/CCLM.2007.113.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Kelsey E. S. Salley, Edmond P. Wickham, Kai I. Cheang, Paulina A. Essah, Nicole W. Karjane, and John E. Nestler
The Journal of Clinical Endocrinology & Metabolism, 2007, Volume 92, Number 12, Page 4546
[2]
Melanie Cree-Green, Ninghe Cai, Jessica E. Thurston, Gregory V. Coe, Lindsay Newnes, Yesenia Garcia-Reyes, Amy D. Baumgartner, Laura Pyle, and Kristen J. Nadeau
Pediatric Diabetes, 2018
[3]
Bahia Namavar Jahromi, Mohammad Hossein Dabbaghmanesh, Pardis Bakhshaie, Mohammad Ebrahim Parsanezhad, Zahra Anvar, Mahshid Alborzi, Afsoon Zarei, and Mina Bakhshaei
Taiwanese Journal of Obstetrics and Gynecology, 2018, Volume 57, Number 4, Page 555
[4]
Baha Oral, Betül Mermi, Müfide Dilek, Güçhan Alanoğlu, and Recep Sütçü
Gynecological Endocrinology, 2009, Volume 25, Number 2, Page 110
[5]
Jana Vrbikova, Bela Bendlova, Marketa Vankova, Katerina Dvorakova, Tereza Grimmichova, Karel Vondra, and Giovanni Pacini
Gynecological Endocrinology, 2009, Volume 25, Number 9, Page 597
[6]
T.G. Valderhaug, J.K. Hertel, N. Nordstrand, P.O. Dale, D. Hofsø, and J. Hjelmesæth
Diabetology & Metabolic Syndrome, 2015, Volume 7, Number 1
[7]
F. Ramezani Tehrani, S. Minooee, and F. Azizi
European Journal of Endocrinology, 2014, Volume 171, Number 2, Page 199
[8]
R. Pasquali and A. Gambineri
Journal of Endocrinological Investigation, 2013, Volume 36, Number 8, Page 648
[9]
S. S. Lim, M. J. Davies, R. J. Norman, and L. J. Moran
Human Reproduction Update, 2012, Volume 18, Number 6, Page 618
[10]
Jana VrbÍková, Hana Zamrazilová, Barbora SedláČková, and Marta Šnajderová
Gynecological Endocrinology, 2011, Volume 27, Number 10, Page 820
[11]
Mohamed Y. Abdel-Rahman, Ahmad H. Abdellah, Salah R. Ahmad, Salah A. Ismail, Heidi Frasure, and William W. Hurd
International Journal of Gynecology & Obstetrics, 2011, Volume 114, Number 3, Page 288
[12]
Angelique J Goverde, H Egbertine Westerveld, Susanne M Verhulst, and Bart CJM Fauser
Expert Review of Obstetrics & Gynecology, 2008, Volume 3, Number 6, Page 775
[13]
Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung, Hyewon Chung, and Wha Young Cho
Endocrine, 2009, Volume 36, Number 2, Page 326
[14]
Susan Awdishu, Nancy I. Williams, Sheila E. Laredo, and Mary Jane De Souza
Sports Medicine, 2009, Volume 39, Number 12, Page 1055

Comments (0)

Please log in or register to comment.
Log in