Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study

Paula Grönroos1 / Olli T. Raitakari2 / Mika Kähönen3 / Nina Hutri-Kähönen4 / Jukka Marniemi5 / Jorma Viikari6 / Terho Lehtimäki7

1Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Tampere, Finland and Department of Clinical Chemistry, University of Turku, Turku, Finland

2Department of Clinical Physiology, University of Turku, Turku, Finland

3Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

4Department of Paediatrics, Tampere University Hospital, Tampere, Finland

5Department of Health and Functional Capacity, Population Research Laboratory, National Public Health Institute, Turku, Finland

6Department of Medicine, University of Turku, Turku, Finland

7Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Tampere, Finland

Corresponding author: Paula Grönroos, MD, PhD, Department of Clinical Chemistry, University of Turku, Kiinamyllynkatu 4-8, PO Box 52, 20521 Turku, Finland Phone: +358-400-937460, Fax: +358-2-3133924,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 5, Pages 592–598, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: 10.1515/CCLM.2007.116, May 2007

Publication History

Received:
2006-12-21
Accepted:
2007-02-11
Published Online:
2007-05-07

Abstract

Background: We examined the influence of apolipoprotein E (apoE) polymorphism on longitudinal changes in serum lipids by following the subjects participating in The Cardiovascular Risk in Young Finns Study over a 21-year period.

Methods: Serum lipids were determined in randomly selected Finnish children and adolescents in 1980 and the subjects were re-examined in 1983, 1986 and after 21 years in 2001. ApoE polymorphism was determined in 1736 participants, and serum lipid values and apoE phenotypes were available for 1233 subjects.

Results: ApoE phenotype-related differences in serum total and low-density lipoprotein (LDL)-cholesterol were maintained throughout the 21-year follow-up from childhood to adulthood, i.e., the apoE ɛ2 allele was consistently associated with lower and the ɛ4 allele with higher total and LDL-cholesterol (p<0.001 for all). In adulthood, there was also a significant apoE phenotype-related difference in high-density lipoprotein (HDL)-cholesterol (p=0.007), and the ɛ2 allele was associated with higher and the ɛ4 allele with lower apoA-I and HDL-cholesterol. In addition, apoB increased in the phenotype order E3/2<E3/3<E4 (E4/3+E4/4) (p<0.001). The LDL-lowering effect of the ɛ2 allele was greater in adulthood than in childhood, i.e., there was a significant apoE phenotype×time interaction (p=0.039) with longitudinal change in LDL-cholesterol.

Conclusions: ApoE polymorphism is associated with lipid levels at different ages and affects the longitudinal change in LDL-cholesterol from childhood to adulthood.

Clin Chem Lab Med 2007;45:592–8.

Keywords: apolipoprotein E polymorphism; cardiovascular risk factors; cholesterol; lipids; long-term follow-up

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Thuy Mai Dang, Valérie Conway, and Mélanie Plourde
Nutrition, 2015, Volume 31, Number 6, Page 807
[2]
Neeraj Kumar Singh, Basu Dev Banerjee, Kiran Bala, Mitrabasu, Aldrin Anthony Dung Dung, and Neelam Chhillar
Neurological Sciences, 2014, Volume 35, Number 7, Page 1075
[3]
Swetha Vijayaraghavan, Walter Maetzler, Matthias Reimold, Christina Unger Lithner, Inga Liepelt-Scarfone, Daniela Berg, and Taher Darreh-Shori
Alzheimer's & Dementia, 2014, Volume 10, Number 5, Page 530
[4]
Alvaro Cerda, Fabiana DV Genvigir, Maria AV Willrich, Simone S Arazi, Marcia MS Bernik, Egidio L Dorea, Marcelo C Bertolami, Andre A Faludi, Mario H Hirata, and Rosario DC Hirata
Lipids in Health and Disease, 2011, Volume 10, Number 1, Page 206
[5]
Taher Darreh-Shori, Anton Forsberg, Negar Modiri, Niels Andreasen, Kaj Blennow, Chelenk Kamil, Hiba Ahmed, Ove Almkvist, Bengt Långström, and Agneta Nordberg
Neurobiology of Aging, 2011, Volume 32, Number 12, Page 2320.e15
[6]
Sanna Tolonen, Vera Mikkilä, Marika Laaksonen, Harri Sievänen, Nina Mononen, Jussi Hernesniemi, Kimmo Vehkalahti, Jorma Viikari, Olli Raitakari, Mika Kähönen, and Terho Lehtimäki
Bone, 2011, Volume 48, Number 5, Page 1058
[7]
D. D. V. Brito, A. P. Fernandes, K. B. Gomes, F. F. Coelho, N. G. Cruz, A. P. Sabino, J. E. Cardoso, P. P. Figueiredo-Filho, R. Diamante, C. R. Norton, and M. O. Sousa
Molecular Biology Reports, 2011, Volume 38, Number 7, Page 4381
[8]
Eva Boes, Stefan Coassin, Barbara Kollerits, Iris M. Heid, and Florian Kronenberg
Experimental Gerontology, 2009, Volume 44, Number 3, Page 136
[9]
Taher Darreh-Shori, Negar Modiri, Kaj Blennow, Souad Baza, Chelenk Kamil, Hiba Ahmed, Niels Andreasen, and Agneta Nordberg
Neurobiology of Aging, 2011, Volume 32, Number 7, Page 1236
[10]
Cláudia N. Ferreira, Maria G. Carvalho, Ana P.S.M. Fernandes, Luciana M. Lima, Andréia A. Loures-Valle, Julizar Dantas, Zoltán Janka, András Palotás, and Marinez O. Sousa
Neurochemistry International, 2010, Volume 56, Number 1, Page 177
[11]
Erik J. Giltay, Arianne K.B. van Reedt Dortland, Aulikki Nissinen, Simona Giampaoli, Tineke van Veen, Frans G. Zitman, Sinikka Bots, and Daan Kromhout
Journal of Affective Disorders, 2009, Volume 115, Number 3, Page 471
[12]
Filomena Addante, Daniele Sancarlo, Massimiliano Copetti, Carlo Scarcelli, Maria Grazia Longo, Valeria Niro, Giulia Paroni, Fabio Pellegrini, Luigi Fontana, and Alberto Pilotto
Rejuvenation Research, 2011, Volume 14, Number 2, Page 111
[13]
Paula Grönroos, Olli T. Raitakari, Mika Kähönen, Nina Hutri-Kähönen, Jukka Marniemi, Jorma Viikari, and Terho Lehtimäki
Clinical Chemical Laboratory Medicine, 2008, Volume 46, Number 2
[14]
Tuomo Nieminen, Mika Kähönen, Leena E Viiri, Paula Grönroos, and Terho Lehtimäki
Pharmacogenomics, 2008, Volume 9, Number 10, Page 1475
[15]
Mary N. Haan and Elizabeth R. Mayeda
Current Cardiovascular Risk Reports, 2010, Volume 4, Number 5, Page 361
[16]
Maryam S. Daneshpour, Mehdi Hedayati, Parisa Eshraghi, and Fereidoun Azizi
European Journal of Lipid Science and Technology, 2010, Volume 112, Number 7, Page 810
[17]
Soile Ruottinen, Tapani Rönnemaa, Harri Niinikoski, Hanna Lagström, Maiju Saarinen, Katja Pahkala, Tuuli Kaitosaari, Jorma Viikari, and Olli Simell
Acta Paediatrica, 2009, Volume 98, Number 10, Page 1667
[18]
Himadri Roy, Shalini Bhardwaj, and Seppo Yla-Herttuala
Human Genetics, 2009, Volume 125, Number 5-6, Page 467
[19]
Jorma Viikari, Harri Niinikoski, Olli T Raitakari, and Olli Simell
Current Opinion in Lipidology, 2009, Volume 20, Number 1, Page 17
[20]
O. T Raitakari, M. Juonala, T. Ronnemaa, L. Keltikangas-Jarvinen, L. Rasanen, M. Pietikainen, N. Hutri-Kahonen, L. Taittonen, E. Jokinen, J. Marniemi, A. Jula, R. Telama, M. Kahonen, T. Lehtimaki, H. K Akerblom, and J. S. Viikari
International Journal of Epidemiology, 2008, Volume 37, Number 6, Page 1220

Comments (0)

Please log in or register to comment.