Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 45, Issue 5


Analytical and clinical performance of three natriuretic peptide tests in the emergency room

Cecile Gorissen / Ruben Baumgarten
  • 2Department of Clinical Chemistry, Atrium Medical Centre, Heerlen, The Netherlands and Present address: Department of Clinical Chemistry, Gelderse Vallei Hospital, Ede, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Monique de Groot
  • 3Department of Clinical Chemistry, Atrium Medical Centre, Heerlen, The Netherlands and Present address: Department of Clinical Chemistry, Amphia Hospital, Breda, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eric van Haren / Hans Kragten / Mathie Leers
Published Online: 2007-05-07 | DOI: https://doi.org/10.1515/CCLM.2007.119


Background: The aim of the present study was to investigate the analytical and diagnostic utility of B-type natriuretic peptide (BNP) and the N-terminus of this prohormone, N-terminal pro-BNP (NT-pro-BNP) testing in the emergency department to identify acute congestive heart failure (CHF).

Methods: A blood sample taken from patients presenting to the emergency department with acute dyspnoea (n=80) was analyzed for natriuretic peptides using three different assays [Triage BNP (Biosite), Centaur BNP (Bayer) and Elecsys NT-pro-BNP (Roche)]. A cardiologist and a pulmonologist, blinded to the actual natriuretic peptide levels, reviewed all test results (including echocardiography, etc.) retrospectively and made a diagnosis of dyspnoea due to CHF or not.

Results: Analytical testing showed good correlation and coefficients of variation of less than 10% for all three assays. Cardiac-related dyspnoea was found in 40 patients (50%). NT-proBNP and BNP values were significantly elevated in these patients. For identifying patients with CHF, BNP and NT-proBNP scored equally well (area under the receiver operating characteristic curve of 0.78, 0.77 and 0.78 for the Biosite, Roche and Bayer assays, respectively).

Conclusions: In general, the different assays tested for BNP and NT-pro-BNP correlate very well in patients with suspected CHF and may aid in the risk stratification process in emergency departments. However, the value must always be interpreted in conjunction with other clinical information. It should also be considered that renal impairment can affect the results.

Clin Chem Lab Med 2007;45:678–84.

Keywords: diagnosis; dyspnoea; heart failure; natriuretic peptides; renal failure

About the article

Corresponding author: Mathie P.G. Leers, PhD, Department of Clinical Chemistry and Haematology, Atrium Medical Centre Parkstad, P.O. Box 4446, 6401 CX Heerlen, The Netherlands Phone: +31-45-5767503,

Received: 2006-12-07

Accepted: 2007-02-15

Published Online: 2007-05-07

Published in Print: 2007-05-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 5, Pages 678–684, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: https://doi.org/10.1515/CCLM.2007.119.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Maithri Siriwardena, Akshay Bagai, Diego Delgado, Heather J. Ross, Evelyn Rozenblyum, Harry Rakowski, Anna Woo, and Paaladinesh Thavendiranathan
The American Journal of Cardiology, 2018
Peter A. McCullough and Aaron Y. Kluger
Journal of the American College of Cardiology, 2018, Volume 71, Number 11, Page 1201
Justin J. Choi and Matthew W. McCarthy
Expert Review of Molecular Diagnostics, 2018, Page 1
Tobias Täger, Ann-Kathrin Wiedergruen, Hanna Fröhlich, Rita Cebola, Anna Corletto, Andrea Horsch, Georg Hess, Karen Slottje, Dietmar Zdunek, Hugo A. Katus, Frank H. Wians, and Lutz Frankenstein
Journal of Cardiac Failure, 2017
Morten T Bøtker, Maren T Jørgensen, Carsten Stengaard, Sophie-Charlott Seidenfaden, Mona Tarpgaard, Asger Granfeldt, Tanja Ø Mortensen, Thorbjørn Grøfte, Kristian D Friesgaard, Rikke Mærkedahl, Anette B Pedersen, Simon Lundorff, Troels Martin Hansen, Hans Kirkegaard, Erika F Christensen, and Christian J Terkelsen
European Heart Journal: Acute Cardiovascular Care, 2017, Page 204887261770998
Jennifer L. Martindale, Abel Wakai, Sean P. Collins, Phillip D. Levy, Deborah Diercks, Brian C. Hiestand, Gregory J. Fermann, Ian deSouza, Richard Sinert, and Christopher Carpenter
Academic Emergency Medicine, 2016, Volume 23, Number 3, Page 223
Jennifer A. Schaub, Steven G. Coca, Dennis G. Moledina, Mark Gentry, Jeffrey M. Testani, and Chirag R. Parikh
JACC: Heart Failure, 2015, Volume 3, Number 12, Page 977
Kaffer Kara, Nils Lehmann, Till Neumann, Hagen Kälsch, Stefan Möhlenkamp, Iryna Dykun, Martina Broecker-Preuss, Noreen Pundt, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, and Amir A. Mahabadi
International Journal of Cardiology, 2015, Volume 183, Page 155
Stephen A. Hill, Ronald A. Booth, P. Lina Santaguida, Andrew Don-Wauchope, Judy A. Brown, Mark Oremus, Usman Ali, Amy Bustamam, Nazmul Sohel, Robert McKelvie, Cynthia Balion, and Parminder Raina
Heart Failure Reviews, 2014, Volume 19, Number 4, Page 421
T.M. Berghaus, T. Haeckel, W. Behr, M. Wehler, W. von Scheidt, and M. Schwaiblmair
Thrombosis Research, 2010, Volume 126, Number 3, Page e201
Gregory Kline, Sarah Weeks, Andrew Lyon, Peter Jamieson, and Robert L. Kline
Clinica Chimica Acta, 2009, Volume 401, Number 1-2, Page 184
T. M. Berghaus, C. Thilo, A. Bluethgen, W. von Scheidt, and M. Schwaiblmair
Advances in Therapy, 2010, Volume 27, Number 9, Page 648

Comments (0)

Please log in or register to comment.
Log in