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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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Volume 45, Issue 5


Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens

Brian J. Morris
  • 1Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Barbara R. Rose
  • 2Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital and The University of Sydney, Sydney, NSW, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-05-07 | DOI: https://doi.org/10.1515/CCLM.2007.127


Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. Because women do not like the sampling procedure, many avoid being screened. Testing for the causative high-risk human papillomavirus (HPV) types, by PCR or other technologies, on self-collected (tampon) samples permits women to be monitored non-invasively. The high negative predictive value of HPV testing means a greater interval between tests, and thus reduces costs. HPV testing lends itself to primary screening. A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation. The higher accuracy of HPV testing should lead to improved cervical cancer prevention.

Clin Chem Lab Med 2007;45:577–91.

Keywords: cervical cancer; cervical screening; human papillomavirus; hybrid capture; polymerase chain reaction; specimen self-collection; tampon

About the article

Corresponding author: Prof. Brian J. Morris, Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia Phone: +61-2-93513688, Fax: +61-2-93512227,

Received: 2006-12-15

Accepted: 2007-02-25

Published Online: 2007-05-07

Published in Print: 2007-05-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 5, Pages 577–591, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: https://doi.org/10.1515/CCLM.2007.127.

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