Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 6

Issues

“Pre-pre” and “post-post” analytical error: high-incidence patient safety hazards involving the clinical laboratory

Michael Laposata
  • 1Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anand Dighe
  • 2Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Conflicts of interest: Drs. Laposata and Dighe are founding stockholders in American Medical Diagnostics.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-06-19 | DOI: https://doi.org/10.1515/CCLM.2007.173

Abstract

Data from recent studies suggest that the highest incidence of laboratory-related errors occurs in the pre-analytical phase of laboratory testing. However, few studies have examined the frequency of errors in laboratory test selection and interpretation. A survey of physicians who use our clinical laboratory demonstrated that the largest number of test ordering errors appear to involve physicians simply ordering the wrong test. Diagnostic algorithms providing guidance for test selection in specific disorders are also used as the basis for the establishment of reflex protocols in the clinical laboratory. The provision of an expert-driven interpretation by laboratory professionals resulted in improvements both in the time to and the accuracy of diagnosis. A survey of our physician staff has shown that in the absence of such an interpretation, for patients being assessed for a coagulation disorder, approximately 75% of the cases would have involved some level of test result misinterpretation.

Clin Chem Lab Med 2007;45:712–9.

Keywords: diagnostic algorithms; laboratory errors; patient safety; post-analytical phase; pre-analytical phase; test interpretation; test selection

About the article

Corresponding author: Michael Laposata, MD, PhD, Massachusetts General Hospital, 55 Fruit Street, GRJ 235, Boston, MA 02114, USA Phone: +1-617-7268172, Fax: +1-617-7263256,


Published Online: 2007-06-19

Published in Print: 2007-06-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 6, Pages 712–719, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.173.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Roberto Verna, Adriana Berumen Velazquez, and Michael Laposata
Annals of Laboratory Medicine, 2019, Volume 39, Number 2, Page 121
[2]
Matthew W Rosenbaum and Jason M Baron
American Journal of Clinical Pathology, 2018
[3]
Maria Salinas, Emilio Flores, Maite López-Garrigós, Maria Leiva-Salinas, Alberto Asencio, Javier Lugo, and Carlos Leiva-Salinas
Clinical Chemistry and Laboratory Medicine (CCLM), 2018, Volume 56, Number 9, Page 1469
[4]
George D. Lundberg
American Journal of Clinical Pathology, 2014, Volume 141, Number 6, Page 767
[5]
Mario Plebani, Michael Laposata, and George D. Lundberg
American Journal of Clinical Pathology, 2011, Volume 136, Number 6, Page 829
[6]
Ashley ND Meyer, Pamela J Thompson, Arushi Khanna, Samir Desai, Benji K Mathews, Elham Yousef, Anita V Kusnoor, and Hardeep Singh
Journal of the American Medical Informatics Association, 2018
[7]
Brita Skodvin, Karina Aase, Anita Løvås Brekken, Esmita Charani, Paul Christoffer Lindemann, and Ingrid Smith
Journal of Antimicrobial Chemotherapy, 2017, Volume 72, Number 9, Page 2666
[8]
Barbara Leone, Noemi Panebianco, and Rossana Cecchi
La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine, 2017
[9]
Piero Cappelletti
La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine, 2017
[10]
Mark L. Graber, Diana Rusz, Melissa L. Jones, Diana Farm-Franks, Barbara Jones, Jeannine Cyr Gluck, Dana B. Thomas, Kelly T. Gleason, Kathy Welte, Jennifer Abfalter, Marie Dotseth, Kathleen Westerhaus, Josanne Smathers, Ginny Adams, Michael Laposata, Quentin Eichbaum, Tina Nabatchi, and Margaret Compton
Diagnosis, 2017, Volume 0, Number 0
[11]
[12]
[13]
Elisabet González Lao, Ángel Salas García, Marta Buxeda Figuerola, Ester Moreno, and Ariadna Hernández Paraire
Open Journal of Social Sciences, 2017, Volume 05, Number 03, Page 243
[14]
Navapun Charuruks
Clinics in Laboratory Medicine, 2017, Volume 37, Number 1, Page 97
[15]
Maryati M. Yusof and Azila Arifin
Journal of Infection and Public Health, 2016, Volume 9, Number 6, Page 766
[16]
Christopher P. Price, Andrew St John, Robert Christenson, Volker Scharnhorst, Michael Oellerich, Patricia Jones, and Howard A. Morris
Clinica Chimica Acta, 2016, Volume 462, Page 183
[17]
Robert L. Schmidt, Jeanne J. Panlener, Suzanne M. Carasso, and Jerry W. Hussong
American Journal of Clinical Pathology, 2016, Volume 145, Number 5, Page 666
[18]
Jaruda Kobkitjaroen, Supot Pongprasobchai, and Panutsaya Tientadakul
Laboratory Medicine, 2015, Volume 46, Number 3, Page 265
[19]
Michael Laposata, Maria A. Proytcheva, Joe C. Rutledge, and Charles W. Stratton
American Journal of Clinical Pathology, 2010, Volume 134, Number 5, Page 706
[20]
Fengfeng Kang, Wei Wang, and Zhiguo Wang
Clinical Chemistry and Laboratory Medicine (CCLM), 2015, Volume 53, Number 11
[21]
Éva Ajzner, Dunja Rogic, Piet Meijer, Ann Helen Kristoffersen, Paolo Carraro, Eser Sozmen, Ana Paula Faria, Sverre Sandberg, and on behalf of the joint Working Grou
Clinical Chemistry and Laboratory Medicine (CCLM), 2015, Volume 53, Number 10
[22]
Jean-Pierre Braun, Nathalie Bourgès-Abella, Anne Geffré, Didier Concordet, and Cathy Trumel
Veterinary Clinical Pathology, 2015, Volume 44, Number 1, Page 8
[23]
Aasne K. Aarsand and Sverre Sandberg
Clinica Chimica Acta, 2014, Volume 432, Page 8
[24]
Bonnie Cole, Jane A. Dickerson, Mark L. Graber, Corinne R. Fantz, Michael Laposata, Kerm Henriksen, Michael L. Astion, and Paul Epner
Clinica Chimica Acta, 2014, Volume 434, Page 1
[26]
Elizabeth M. Van Cott
Clinica Chimica Acta, 2014, Volume 427, Page 188
[27]
Satid Thammasitboon, Supat Thammasitboon, and Geeta Singhal
Current Problems in Pediatric and Adolescent Health Care, 2013, Volume 43, Number 9, Page 242
[28]
Elissa Passiment, James L. Meisel, John Fontanesi, George Fritsma, Samir Aleryani, and Marisa Marques
Journal of General Internal Medicine, 2013, Volume 28, Number 3, Page 453
[29]
Stacy E. Walz and Teresa P. Darcy
Clinics in Laboratory Medicine, 2013, Volume 33, Number 1, Page 183
[30]
Oxana Tcherniantchouk, Michael Laposata, and Marisa B. Marques
American Journal of Hematology, 2013, Volume 88, Number 1, Page 82
[31]
Nada Majkić-Singh and Zorica Šumarac
Journal of Medical Biochemistry, 2012, Volume 31, Number 3
[32]
Ángeles Giménez Marín, Pedro Molina Mendoza, José Joaquin Ruiz Arredondo, Federico Acosta González, Marisa López Pérez, Manolo Jiménez Cueva, Teresa Cueto Santamaría, Rosa Olmedo Sánchez, Mercedes López Somosierras, Francisco Rivas Ruiz, and María del Mar Pérez Hidalgo
Revista del Laboratorio Clínico, 2010, Volume 3, Number 4, Page 161
[33]
Robert Hawkins
Annals of Laboratory Medicine, 2012, Volume 32, Number 1, Page 5
[34]
Viroj Wiwanitkit
Future Virology, 2012, Volume 7, Number 1, Page 53
[35]
Mario Plebani
Clinica Chimica Acta, 2009, Volume 404, Number 1, Page 16
[36]
Mario Plebani
Clinica Chimica Acta, 2009, Volume 404, Number 1, Page 46
[37]
Adolfo Romero, Andrés Cobos, Ana López-León, Germán Ortega, and Manuel Muñoz
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 12
[38]
Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 7
[39]
Pär I. Johansson, Louise Bochsen, Søren Andersen, and Dorthe Viuff
Transfusion, 2008, Volume 48, Number 11, Page 2377

Comments (0)

Please log in or register to comment.
Log in