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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 45, Issue 7

Issues

Tumor necrosis factor-α and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions

Mohamed El-Far
  • 1Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ibrahim H. El-Sayed
  • 2Molecular Biology Department, Institute of Genetic Engineering and Biotechnology, Menofia University, Sadat City, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Abd El-Gawad El-Motwally
  • 3Obstetrics and Gynecology Department, Faculty of Medicine, Mansoura University Hospital, Mansoura, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ikbal Abou Hashem / Nadia Bakry
Published Online: 2007-07-08 | DOI: https://doi.org/10.1515/CCLM.2007.138

Abstract

Background: Many factors have been implicated in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). The current study was conducted to determine the possible role of antioxidant status and tumor necrosis factor-α (TNF-α) in URSA.

Methods: Reduced glutathione (GSH), glutathione reductase (GSH-R), glutathione peroxidase (GSH-PX), catalase (CAT), superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and TNF-α were assayed in women suffering unexplained first-trimester abortions. Two groups were included, the first represented by 24 women with URSA (number of abortions 3–5) and the second included 16 women with URSA (number of abortions >5). The control group included 20 women within their first trimester of pregnancy and 20 non-pregnant healthy females within their follicular phase.

Results: We observed that the antioxidant levels measured were significantly lower in URSA groups than in the control group (p<0.05 for each comparison). Higher TNF-α, MDA and NO production were detected in URSA groups compared to controls (p<0.05 for each comparison). URSA 3–5 was associated with significantly higher levels of antioxidants and lower levels of TNF-α compared to levels in URSA >5.

Conclusions: Impaired antioxidant defense and an increase in oxidative reactive species may be responsible for recurrent abortion due to possible damage produced by their generation. In addition, the level of TNF-α apparently contributes to the pathogenesis of URSA.

Clin Chem Lab Med 2007;45:879–83.

Keywords: antioxidant; free radicals; miscarriage; tumor necrosis factor-α; unexplained recurrent spontaneous abortion

About the article

Corresponding author: Prof. Dr. Mohamed El-Far, Head of Division of Biochemistry, Faculty of Science, Mansoura University, Mansoura, Egypt Phone:+20-502248348, Fax: +20-502246254


Received: 2007-01-23

Accepted: 2007-03-05

Published Online: 2007-07-08

Published in Print: 2007-07-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 7, Pages 879–883, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.138.

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