Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 45, Issue 7


Tumor necrosis factor-α and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions

Mohamed El-Far
  • 1Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ibrahim H. El-Sayed
  • 2Molecular Biology Department, Institute of Genetic Engineering and Biotechnology, Menofia University, Sadat City, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Abd El-Gawad El-Motwally
  • 3Obstetrics and Gynecology Department, Faculty of Medicine, Mansoura University Hospital, Mansoura, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ikbal Abou Hashem / Nadia Bakry
Published Online: 2007-07-08 | DOI: https://doi.org/10.1515/CCLM.2007.138


Background: Many factors have been implicated in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). The current study was conducted to determine the possible role of antioxidant status and tumor necrosis factor-α (TNF-α) in URSA.

Methods: Reduced glutathione (GSH), glutathione reductase (GSH-R), glutathione peroxidase (GSH-PX), catalase (CAT), superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and TNF-α were assayed in women suffering unexplained first-trimester abortions. Two groups were included, the first represented by 24 women with URSA (number of abortions 3–5) and the second included 16 women with URSA (number of abortions >5). The control group included 20 women within their first trimester of pregnancy and 20 non-pregnant healthy females within their follicular phase.

Results: We observed that the antioxidant levels measured were significantly lower in URSA groups than in the control group (p<0.05 for each comparison). Higher TNF-α, MDA and NO production were detected in URSA groups compared to controls (p<0.05 for each comparison). URSA 3–5 was associated with significantly higher levels of antioxidants and lower levels of TNF-α compared to levels in URSA >5.

Conclusions: Impaired antioxidant defense and an increase in oxidative reactive species may be responsible for recurrent abortion due to possible damage produced by their generation. In addition, the level of TNF-α apparently contributes to the pathogenesis of URSA.

Clin Chem Lab Med 2007;45:879–83.

Keywords: antioxidant; free radicals; miscarriage; tumor necrosis factor-α; unexplained recurrent spontaneous abortion

About the article

Corresponding author: Prof. Dr. Mohamed El-Far, Head of Division of Biochemistry, Faculty of Science, Mansoura University, Mansoura, Egypt Phone:+20-502248348, Fax: +20-502246254

Received: 2007-01-23

Accepted: 2007-03-05

Published Online: 2007-07-08

Published in Print: 2007-07-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 7, Pages 879–883, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.138.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Todd M. Everson, Maya Kappil, Ke Hao, Brian P. Jackson, Tracy Punshon, Margaret R. Karagas, Jia Chen, and Carmen J. Marsit
Environmental Research, 2017, Volume 158, Page 233
Hazem K. Ghneim and Mashael M. Alshebly
Journal of Korean Medical Science, 2016, Volume 31, Number 1, Page 98
Guanhui Liu, Yulan Dong, Zixu Wang, Jing Cao, and Yaoxing Chen
Stress, 2014, Volume 17, Number 6, Page 494
Özgür Bilgin Yiyenoğlu, Mete Gürol Uğur, Hüseyin Çağlayan Özcan, Günay Can, Ebru Öztürk, Özcan Balat, and Özcan Erel
Archives of Gynecology and Obstetrics, 2014, Volume 289, Number 6, Page 1337
Sajal Gupta, Jennifer Fedor, Kelly Biedenharn, and Ashok Agarwal
Expert Review of Obstetrics & Gynecology, 2013, Volume 8, Number 6, Page 607
Farah Parveen and Suraksha Agrawal
American Journal of Reproductive Immunology, 2013, Volume 70, Number 6, Page 529
S.W. Lyu, H. Song, J.A. Yoon, Mi-Uk Chin, S.R. Sung, Y.S. Kim, W.S. Lee, T.K. Yoon, D.H. Cha, and S.H. Shim
Placenta, 2013, Volume 34, Number 2, Page 133
Hui-Juan Gao, Yi-Min Zhu, Wei-Hua He, Ai-Xia Liu, Min-Yue Dong, Min Jin, Jian-Zhong Sheng, and He-Feng Huang
Molecular Biology Reports, 2012, Volume 39, Number 9, Page 9179
Mohamed El-Far, Mohamed Elshal, Manar Refaat, and Ibrahim M. El-Sherbiny
Drug Development and Industrial Pharmacy, 2011, Volume 37, Number 12, Page 1481
J. Ben-Nagi, J. Miell, D. Mavrelos, J. Naftalin, C. Lee, and D. Jurkovic
Reproductive BioMedicine Online, 2010, Volume 21, Number 5, Page 610
Francesca Raffaelli, Laura Nanetti, Arianna Vignini, Laura Mazzanti, Stefano Raffaele Giannubilo, Claudia Maria Curzi, Angelo Turi, Paola Vitali, and Andrea Luigi Tranquilli
Fertility and Sterility, 2010, Volume 93, Number 6, Page 1976
Mohamed El-Far, Abd El-Gawad El-Motwally, Ikbal Abou Hashem, and Nadia Bakry
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 11
M. El-Far, I. H. El-Sayed, A. E. El-Motwally, I. A. Hashem, and N. Bakry
Journal of Physiology and Biochemistry, 2009, Volume 65, Number 2, Page 175
P. Redecha, N. van Rooijen, D. Torry, and G. Girardi
Blood, 2009, Volume 113, Number 17, Page 4101

Comments (0)

Please log in or register to comment.
Log in