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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 8

Issues

Changes in platelet count and indices in pulmonary tuberculosis

Ergun Tozkoparan / Omer Deniz / Ergun Ucar / Hayati Bilgic / Kudret Ekiz
Published Online: 2007-08-09 | DOI: https://doi.org/10.1515/CCLM.2007.194

Abstract

Background: Recent studies show that platelets have important roles in the immune system. Little is known about the clinical significance of platelet indices. Changes in platelet indices, including platelet distribution width (PDW), mean platelet volume (MPV) and plateletcrit, in pulmonary tuberculosis were investigated.

Methods: Platelet indices were quantified in 82 patients with active tuberculosis and 87 patients with inactive or non-tuberculous disease (controls). Radiological extent of the disease was assessed.

Results: There were significantly higher PDW (40.9±23.5% vs. 27.0±14.5%), MPV (10.05±2.36 vs. 8.83±1.47 fL) and plateletcrit (0.330±0166% vs. 0.266±0.128%) values in the active tuberculosis group, which decreased significantly with anti-tuberculous therapy. Erythrocyte sedimentation rate and plateletcrit showed significant correlation (r=0.54 and r=0.66) with radiological extent of tuberculosis, while PDW and MPV correlations with radiological extent of tuberculosis were also significant but weaker (r=0.31 and r=0.23). In a subpopulation of controls with pneumonia, which leads to acute phase reaction, PDW, MPV and plateletcrit values were significantly lower than in the tuberculosis group.

Conclusions: We suggest that PDW, MPV and plateletcrit change in tuberculosis and that these changes may not reflect only acute phase reaction and disease activity. The potential role of platelet indices in tuberculosis immunopathogenesis remains to be investigated.

Clin Chem Lab Med 2007;45:1009–13.

Keywords: mean platelet volume; plateletcrit; platelet distribution width; platelet indices; tuberculosis

About the article

Corresponding author: Dr. Ergun Tozkoparan, Department of Pulmonary Medicine, Gulhane Military Medical Academy, Ankara, Turkey


Received: 2007-01-30

Accepted: 2007-04-19

Published Online: 2007-08-09

Published in Print: 2007-08-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 8, Pages 1009–1013, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.194.

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