Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 45, Issue 8


Exhaled breath condensate: a new method for lung disease diagnosis

Ivana Čepelak
  • 1Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Slavica Dodig
  • 2Srebrnjak Children's Hospital, Reference Center for Clinical Pediatric Allergology of the Ministry of Health and Social Welfare, Zagreb, Croatia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar


Analysis of exhaled breath composition in lung disease patients can indirectly point to biochemical changes that occur in the fluid lining airway surfaces. The parameters of redox and acid-base changes, and of inflammatory changes relevant in the pathogenesis of most pulmonary diseases are currently most widely determined in exhaled breath condensate. The collection of exhaled breath condensate is a safe, non-invasive, easy and simple diagnostic procedure that is suitable for longitudinal studies and applicable in patients of all age groups, irrespective of the disease severity. In spite of many scientific studies involving lung disease patients, methodology for exhaled breath condensate collection and analysis has not yet been realized for daily utilization. Additional studies of the exact origin of condensate constituents and standardization of the overall analytical process, including collection, storage, analysis and result interpretation, are needed. Irrespective of these limitations, further investigation of this sample type is fully justified by the fact that classical specimens used in the management of pulmonary disease are either obtained by invasive procedures (e.g., induced sputum, biopsy, bronchoalveolar lavage) or cannot provide appropriate information (e.g., urine, serum). Analysis of exhaled breath condensate in the future might contribute significantly to our understanding of the physiological and pathophysiological processes in lungs, to early detection, diagnosis and follow up of disease progression, and to evaluation of therapeutic response.

Clin Chem Lab Med 2007;45:945–52.

Keywords: asthma; exhaled breath condensate; lung disease

About the article

Corresponding author: Ivana Čepelak, Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 2, 10000 Zagreb, Croatia Phone: +385-1-4612716, Fax: +385-1-4612606,

Received: 2007-02-17

Accepted: 2007-05-03

Published in Print: 2007-08-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 8, Pages 945–952, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.326.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Sergio Mosquera Restrepo , Marta C. Mesa Villanueva, and Mauricio Rojas López
Medicina y Laboratorio, 2017, Volume 23, Number 11-12, Page 513
Courtney M. Wheatley, Nicholas A. Cassuto, William T. Foxx-Lupo, and Eric M. Snyder
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2010, Volume 4, Page CCRPM.S4718
Shuyi Ma, Jaeyun Sung, Andrew T. Magis, Yuliang Wang, Donald Geman, Nathan D. Price, and Chuhsing Kate Hsiao
PLoS ONE, 2014, Volume 9, Number 10, Page e110840
Ž. Vlašić, S. Dodig, I. Čepelak, R. Zrinski Topić, J. Živčić, B. Nogalo, and M. Turkalj
Journal of Asthma, 2009, Volume 46, Number 1, Page 81
Slavica Dodig, Ivana Čepelak, Željka Vlašić, Renata Zrinski Topić, and Sanda Banović
Laboratory Medicine, 2010, Volume 41, Number 12, Page 728
Efstathia M. Konstantinidi, Andreas S. Lappas, Anna S. Tzortzi, and Panagiotis K. Behrakis
The Scientific World Journal, 2015, Volume 2015, Page 1
Sharron Chow, Charlotte Campbell, Alessandra Sandrini, Paul S. Thomas, Anthony R. Johnson, and Deborah H. Yates
Respiratory Medicine, 2009, Volume 103, Number 8, Page 1091
S. Banović, M. Navratil, Ž. Vlašić, R. Zrinski Topić, and S. Dodig
Journal of Asthma, 2011, Volume 48, Number 7, Page 667
Courtney M. Wheatley, Brad W. Wilkins, and Eric M. Snyder
Exercise and Sport Sciences Reviews, 2011, Volume 39, Number 3, Page 155
Slavica Dodig, Darko Richter, and Renata Zrinski-Topić
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 4
P.-J. Cardona
Infection, 2009, Volume 37, Number 2, Page 80
Slavica Dodig, Željka Vlašić, Ivana Čepelak, Renata Zrinski Topić, Mirjana Turkalj, and Boro Nogalo
Journal of Clinical Laboratory Analysis, 2009, Volume 23, Number 1, Page 34

Comments (0)

Please log in or register to comment.
Log in