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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 45, Issue 9

Issues

Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients

Jaroslav A. Hubacek
  • 1Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic and Cardiovascular Research Center, Prague, Czech Republic
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/ Silvie Bloudíčková
  • 2Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic and Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Romana Bohuslavová
  • 3Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic and Cardiovascular Research Center, Prague, Czech Republic
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/ Petr Táborský
  • 4Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Vladimír Polakovič
  • 5Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Magdaléna Sazamová
  • 6Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Eva Svítilová
  • 7Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jičí Vlasák
  • 8Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Iva Sojková
  • 9Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Miroslav Ryba
  • 10Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Petr Knetl
  • 11Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Martin Ullrych
  • 12Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Radim Drahozal
  • 13Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Veronika Pavuková
  • 14Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Beata Pavlíková
  • 15Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Drahomíra Fischlová
  • 16Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Magdaléna Mokrejšová
  • 17Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Hana Chmelíčková
  • 18Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Eva Pauchová
  • 19Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Pavel Vyskočil
  • 20Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Zuzana Nýdlová
  • 21Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jaroslav Kopenec
  • 22Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Petr Fixa
  • 23Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jan Hajný
  • 24Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Petr Bubeníček
  • 25Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Petr Syrovátka
  • 26Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jana Zahálková
  • 27Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Stanislav Šurel
  • 28Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Zdeněk Hobzek
  • 29Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Aleš Hrubý
  • 30Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jana Suchanová
  • 31Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Světlana Vaňková
  • 32Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Jana Brabcová
  • 33Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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/ Ondřej Viklický MIA Group
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.141

Abstract

Background: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications.

Methods: Ghrelin variants Arg51>Gln and Leu72> Met were analyzed by PCR-RFLP in 210 hemodialyzed patients, prospectively followed up for 15 months. Changes in body mass index, triglycerides, total cholesterol and albumin over time (after 3, 6, 9, 12 and 15 months of dialysis) were analyzed in subgroups divided according to ghrelin genotypes.

Results: Carriers of at least one of the Gln51 and Met72 alleles lost body weight more quickly than Arg51Arg/Leu72Leu homozygotes (p<0.01). Carriers of the Gln51 allele were at higher risk of developing high cholesterol levels (p<0.01).

Conclusions: Common ghrelin variants may have an effect on changes in biochemical and anthropometric parameters in hemodialyzed patients over time and could be used in the future to plan individualized therapy.

Clin Chem Lab Med 2007;45:1121–3.

Keywords: cholesterol; ghrelin; polymorphism; renal failure

About the article

Corresponding author: Jaroslav A. Hubacek, IKEM, DEM, – Laboratory for Molecular Genetics, Videnska 1958/9, 140 21, Prague 4, Czech Republic Phone: +420-261-363367, Fax: +420-261-721666,


Received: 2006-09-15

Accepted: 2007-01-11

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1121–1123, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.141.

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