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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 9

Issues

Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)

Iwona Wybranska
  • 1Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Malgorzata Malczewska-Malec
  • 2Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Lukasz Partyka
  • 3Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Beata Kiec-Wilk
  • 4Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Katarzyna Kosno
  • 5Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Iwona Leszczynska-Golabek
  • 6Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Anna Zdzienicka
  • 7Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Anna Gruca
  • 8Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Malgorzata Kwasniak
  • 9Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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/ Aldona Dembinska-Kiec
  • 10Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Krakow, Poland
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Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.142

Abstract

Background: New tools to identify genotype-phenotype interactions need to be described and implemented. The aim of this study was to identify correlation between the risk originating from gene variation and diet-dependent development of insulin resistance.

Methods: Insulin output in terms of area under the curve after an oral glucose tolerance test (AUC Ins OGTT) and lipid tolerance tests (AUC Ins OLTT) were measured in 167 overweight/obese patients. Estimation of the 18 common gene polymorphisms for obesity risk and standard phenotyping were performed.

Results: Insulin output (AUC Ins OGTT) correlated strongly between both insulin treatments across the whole group. However, within the genotype sub-groups, correlation was lower or did not exist. Using a nutrient-induced insulin output ratio (NIOR), calculated as AUC Ins OLTT/AUC Ins OGTT, values ranged from 0.42 to 5.83 and correlated significantly with body mass index (BMI) and leptin, but not with age, gender, waist-to-hip ratio (WHR) and homeostasis model assessment of insulin resistance (HOMA-IR) or plasma adiponectin. High NIOR was found in a subgroup of carriers of rare allelic variants of genes characteristic for poorer tolerance to lipids in the diet. Low NIOR values were found within a sub-group with rare genetic variants regulating carbohydrate metabolism. Thus, the new insulin index NIOR may distinguish gene variant carriers into groups of glucose- or lipid-sensitive phenotypes.

Conclusions: We suggest that the OLTT/OGTT insulin output ratio (NIOR) may be predictive for identifying individuals who are phenotypically susceptible to insulin resistance in response to high fat or carbohydrate in their habitual diet.

Clin Chem Lab Med 2007;45:1124–32.

Keywords: gene polymorphisms; individualized nutrition; insulin resistance; metabolic syndrome; obesity; prognostic marker

About the article

Corresponding author: Dr. Iwona Wybranska, Department of Clinical Biochemistry, The Jagiellonian University, Medical College, Kopernika 15a, 31-501 Krakow, Poland Phone: +48-1-24248799, Fax: +48-1-24214073,


Received: 2006-09-18

Accepted: 2007-01-15

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1124–1132, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.142.

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