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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
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1437-4331
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Volume 45, Issue 9

Issues

The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects

Kazuhiko Kotani
  • 1Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan and Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Naoki Sakane
  • 2Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kyoko Saiga
  • 3Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kokoro Tsuzaki
  • 4Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hisashi Shimohiro / Masahiko Tabata / Youichi Kurozawa
  • 7Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.253

Abstract

Background: The possible effects of the uncoupling protein-1 (UCP-1) gene −3826A/G polymorphism on hypertension (HT) have yet to be elucidated.

Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the −3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.

Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08–1.13)] and BMI [OR 1.13 (1.06–1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08–4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00–3.57)] was also an independent significant factor for HT in the relatively older subgroup (≥60 years).

Conclusions: The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.

Clin Chem Lab Med 2007;45:1186–9.

Keywords: blood pressure; elderly; gender; hypertension; single nucleotide polymorphisms (SNPs)

About the article

Corresponding author: Kazuhiko Kotani, MD, PhD, Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan Phone: +81-859-38-6113, Fax: +81-859-38-6110,


Received: 2007-03-01

Accepted: 2007-05-04

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1186–1189, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.253.

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