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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

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Volume 45, Issue 9


Intra-individual variation in creatinine and cystatin C

Niluka Bandaranayake / Thelma Ankrah-Tetteh / Sethsiri Wijeratne / Ramasamyiyer Swaminathan
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.256


Background: Serum creatinine and cystatin C are measured in the assessment of glomerular filtration rate. Biological variation of an analyte is an important determinant of its usefulness. Intra-individual variation in serum creatinine and cystatin C in healthy subjects was determined in this study.

Methods: Weekly blood samples were taken from 10 healthy subjects and analysed for creatinine (kinetic Jaffe method) and for cystatin C (by nephelometry).

Results: Intra-individual variations for serum creatinine and cystatin C were 6.1% and 4.55%, respectively. Index of individuality values were similar for the analytes (0.35 for both).

Conclusion: Intra-individual variations for serum creatinine and cystatin C were similar in healthy subjects.

Clin Chem Lab Med 2007;45:1237–9.

Keywords: creatinine; cystatin C; glomerular filtration rate; intra-individual variation

About the article

Corresponding author: Prof. R. Swaminathan, Department of Chemical Pathology, St. Thomas' Hospital, 5th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, UK Phone: +44-20-71881285 ext 3542, Fax: +44-20-79284226,

Received: 2007-03-26

Accepted: 2007-05-14

Published Online: 2007-09-11

Published in Print: 2007-09-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1237–1239, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.256.

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