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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 45, Issue 9

Issues

Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome

Loredan Stefan Niculescu
  • 1Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jamila Fruchart-Najib
  • 2Department of Atherosclerosis, INSERM U545, Pasteur Institute of Lille and University of Lille 2, Lille, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jean-Charles Fruchart
  • 3Department of Atherosclerosis, INSERM U545, Pasteur Institute of Lille and University of Lille 2, Lille, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anca Sima
  • 4Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.257

Abstract

Background: Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis.

Methods: The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed −1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters.

Results: We obtained higher frequency for −1.131C compared to c.56G alleles, both mainly distributed in overweight subjects. Body mass index and triglyceride levels were higher in −1.131C allele carriers in metabolic syndrome patients, but were not significantly different in c.56G carriers compared to those with the native gene. Metabolic syndrome −1.131C homozygotes presented lower high-density lipoprotein cholesterol and higher glucose levels compared to subjects with the native gene. Total cholesterol, low-density lipoprotein cholesterol and insulin were not different between −1.131C or c.56G allele carriers and those with the native gene.

Conclusions: Our results demonstrate an independent risk for −1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome.

Clin Chem Lab Med 2007;45:1133–9.

Keywords: apolipoprotein A-V; gene polymorphism; metabolic syndrome; obesity

About the article

Corresponding author: Loredan Stefan Niculescu, Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, 8 B.P. Hasdeu Street, P.O. Box 35-14, Bucharest 050568, Romania Phone +40-21-3194518, Fax +40-21-3194519,


Received: 2006-11-06

Accepted: 2007-04-05

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1133–1139, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.257.

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