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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
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1437-4331
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Volume 45, Issue 9

Issues

Apolipoprotein E polymorphism – a risk factor for metabolic syndrome

Anca Sima
  • 1Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alexandru Iordan
  • 2Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Camelia Stancu
  • 3Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.258

Abstract

Background: Metabolic syndrome is closely related to several disturbances in lipid and lipoprotein metabolism. The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications.

Methods: The study included 279 subjects divided into three groups: 1) control subjects, 2) metabolic syndrome patients, and 3) obese patients with coronary heart disease. All subjects were characterized by body mass index, and plasma levels of glucose, triglycerides, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). ApoE genotypes were identified by PCR-restriction fragment length polymorphism using genomic DNA.

Results: Statistical analysis of plasma parameters showed that subjects in groups 2 and 3 had higher levels of triglycerides and lower levels of HDL-C compared to group 1. The frequencies of apoE genotypes determined in this Romanian population (65% for E3/3, 19.6% for E4/3, 9.5% for E3/2, 4.1% for E2/2, 0.6% for E4/4, 1.3% for E4/2) were in agreement with those reported for other Caucasian populations. The distribution of apoE alleles indicated a higher frequency of ɛ4 in groups 2 and 3. There was a higher frequency of the apoE4/3 genotype in groups 2 and 3, which was significantly correlated with higher levels of triglycerides and lower levels of HDL-C.

Conclusions: Correlations of apoE genotypes with these markers indicate that the ɛ4 allele is an independent risk factor for metabolic syndrome.

Clin Chem Lab Med 2007;45:1149–53.

Keywords: apolipoprotein E genotypes; coronary heart disease; dyslipidemia; metabolic syndrome; obesity

About the article

Corresponding author: Anca Sima, PhD, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania Phone: +40-21-319-4518, Fax: +40-21-319-4519,


Received: 2006-11-06

Accepted: 2007-03-21

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1149–1153, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.258.

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