Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 45, Issue 9

Issues

Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome

Vesna Dimitrijevic-Sreckovic
  • 1Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Emina Colak / Predrag Djordjevic
  • 3Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Drasko Gostiljac
  • 4Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Branko Sreckovic / Srdjan Popovic
  • 6Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Fadil Canovic
  • 7Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Miroljub Ilic
  • 8Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Radmila Obrenovic / Vladan Vukcevic / Dragan Nikolic
  • 11Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tanja Nisic
  • 12Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gordana Milic
  • 13Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gordana Pejcic
  • 14Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.259

Abstract

Background: The aim of this study was to examine prothrombogenic factors and antioxidative defense in obese children and adolescents with pre-metabolic and metabolic syndrome, and to analyze insulin secretion and resistance, early glycoregulation disorders and lipid status.

Methods: Insulin sensitivity was determined using the homeostasis model assessment for insulin resistance (HOMA-IR), while insulin secretion was determined using the homeostasis model assessment β (HOMA-β). Prothrombogenic factors analyzed were plasma plasminogen activator inhibitor-1 (PAI-1) and fibrinogen. Superoxide dismutase and glutathione peroxidase were measured as markers of antioxidative defense.

Results: Patients with metabolic syndrome were characterized with increased body mass index (BMI), waist circumference, and HOMA-IR and HOMA-β levels, and all had increased blood pressure and triglyceride levels, low high-density lipoprotein cholesterol levels, increased PAI-1 levels and reduced antioxidative defense levels. Patients with pre-metabolic syndrome had higher levels of basal and mean insulinemia during an oral glucose tolerance test, higher levels of HOMA-β and lower levels of antioxidative defense compared to patients with metabolic syndrome.

Conclusions: Negative correlations between antioxidative defense parameters and BMI, abdominal obesity, insulin secretion, systolic blood pressure and atherogenic lipid factors, as well as correlations between PAI-1 and insulin resistance and basal glycemia in the metabolic syndrome group contribute to accelerated atherosclerosis. Positive correlations between PAI-1 and waist circumference and BMI, and negative correlations between BMI and antioxidative defense in the pre-metabolic syndrome patients show that this early stage preceding the metabolic syndrome is also characterized by atherosclerotic complication risks and evident hyperinsulinism and insulin resistance.

Clin Chem Lab Med 2007;45:1140–4.

Keywords: antioxidative defense; children/adolescents; metabolic syndrome; plasminogen activator inhibitor-l; pre-metabolic syndrome

About the article

Corresponding author: Vesna Dimitrijevic-Sreckovic, MD, PhD, Associated Professor, Krupanjska 24, 11000 Belgrade, Serbia Phone: +381-64-2028571, Fax: +381-11-2685357,


Received: 2006-11-01

Accepted: 2007-03-21

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1140–1144, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.259.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Gordana Dragović, Mirjana Sumarac-Dumanovic, Al Musalhi Khawla, Ivan Soldatović, Mladen Andjić, Djordje Jevtović, and Devaki Nair
Experimental and Molecular Pathology, 2018
[2]
Cecilie Utke Rank, Nina Toft, Ruta Tuckuviene, Kathrine Grell, Ove Juul Nielsen, Thomas Leth Frandsen, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Ulf Tedgård, Helene Hallböök, Ellen Ruud, Kirsten Brunsvig Jarvis, Petter Quist-Paulsen, Pasi Huttunen, Ulla Wartiovaara-Kautto, Ólafur Gísli Jónsson, Sonata Saulyte Trakymiene, Laimonas Griškevičius, Kadri Saks, Mari Punab, and Kjeld Schmiegelow
Blood, 2018, Volume 131, Number 22, Page 2475
[3]
Yu-Cheng Lin, Tun-Jen Hsiao, and Pau-Chung Chen
World Journal of Gastroenterology, 2009, Volume 15, Number 45, Page 5654
[4]
Branko Sreckovic, Vesna Dimitrijevic Sreckovic, Ivan Soldatovic, Emina Colak, Mirjana Sumarac-Dumanovic, Hristina Janeski, Nenad Janeski, Jasna Gacic, and Igor Mrdovic
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017, Volume 11, Number 3, Page 179
[5]
Yu-Cheng Lin, Tun-Jen Hsiao, and Pau-Chung Chen
Chronobiology International, 2009, Volume 26, Number 4, Page 740
[6]
Fernanda Vidigal, Andréia Ribeiro, Nancy Babio, Jordi Salas-Salvadó, and Josefina Bressan
Diabetology & Metabolic Syndrome, 2015, Volume 7, Number 1, Page 6
[7]
Vesna Dimitrijevic-Sreckovic, Ivan Soldatovic, Djordje Culafic, Branko Sreckovic, Srdjan Popovic, Predrag Djordjevic, and Tatjana Ille
Metabolic Syndrome and Related Disorders, 2013, Volume 11, Number 6, Page 427
[8]
Lucie Vávrová, Jana Kodydková, Miroslav Zeman, Magdaléna Dušejovská, Jaroslav Macášek, Barbora Stanková, Eva Tvrzická, and Aleš Žák
Obesity Facts, 2013, Volume 6, Number 1, Page 39
[9]
Jasminka Korolija and Jelena Stanisic
Zbornik Instituta za pedagoska istrazivanja, 2009, Volume 41, Number 2, Page 461
[10]
Abayomi O. Akanji, Abdulwahab N. Al-Isa, and Lukman Thalib
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 10
[11]
Michiko Nagata, Shinji Ijichi, Teruto Hashiguchi, Hirofumi Morioka, and Kimiyoshi Arimura
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2009, Volume 3, Number 2, Page 96

Comments (0)

Please log in or register to comment.
Log in