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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

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1437-4331
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Volume 45, Issue 9 (Sep 2007)

Issues

Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study

Peteris Tretjakovs
  • 1Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Gustavs Latkovskis
  • 2Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Latvian Centre of Cardiology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Normunds Licis
  • 3Latvian Biomedical Research Centre, Riga, Latvia
/ Dace Juhnevica
  • 4Faculty of Medicine, University of Latvia, Riga, Latvia and Latvian Centre of Cardiology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Antra Jurka
  • 5Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Inga Bormane
  • 6Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Juris I. Aivars
  • 7Faculty of Biology, University of Latvia, Riga, Latvia
/ Agnis Stifts
  • 8Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia
/ Valdis Pirags
  • 9Faculty of Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.260

Abstract

Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter –174G/C (IL-6 –174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD).

Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606). IL-6 –174G/C genotype was previously analysed and only homozygotes with the CC genotype (n=10) or GG genotype (n=10) were selected. IR was measured using the homeostasis model assessment for IR (HOMA-IR) method.

Results: Differences in age, body mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), hypertension, IL-6, C-reactive protein and HOMA-IR were not significant between the genotypes (p>0.05), but analysis of a homogeneity-of-slopes model showed that genotype had a significant influence on HOMA-IR (p=0.037), and the interaction between genotype and HDL-C had a pronounced tendency to affect HOMA-IR (p=0.058). Using multiple regression analysis, we found that HDL-C had a significant effect on HOMA-IR (p=0.023), and TG had a tendency to affect HOMA-IR (p=0.066) only in the CC genotype.

Conclusions: Our data show that IL-6 –174G/C polymorphism may have a significant effect on IR. A comparison between the effects of various cardiovascular risk factors showed that HDL-C may have a significant effect on HOMA-IR in the CC genotype but not in the GG genotype. Further research is needed to test the preliminary results.

Clin Chem Lab Med 2007;45:1145–8.

Keywords: adiposity; coronary heart disease; genotype; high-density lipoprotein cholesterol; insulin resistance; interleukin-6

About the article

Corresponding author: Peteris Tretjakovs, PhD, Institute of Experimental and Clinical Medicine, University of Latvia, Ojara Vaciesa Street 4, Riga 1004, Latvia Phone: +371-7069309, Fax: +371-7612038,


Received: 2006-09-25

Accepted: 2007-04-26

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.260.

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