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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 45, Issue 9 (Sep 2007)

Issues

The association between lipid profiles and breast cancer among Taiwanese women

Shun-Jen Chang
  • 1Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
/ Ming-Feng Hou
  • 2Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
/ Shih-Meng Tsai
  • 3Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
/ Szu-Hsien Wu
  • 4Department of Surgery, I-Lan Hospital, I-Lan, Taiwan and Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
/ Linda Ann Hou
  • 5Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
/ Hsu Ma
  • 6Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
/ Tzyy-Yuan Shann
  • 7Department of Surgery, I-Lan Hospital, I-Lan, Taiwan
/ Szu-Hua Wu
  • 8Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
/ Li-Yu Tsai
  • 9Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.263

Abstract

Background: Breast cancer incidence increased seven-fold from 1979 to 2002, and it has become the second most common cancer in Taiwanese women. Although the relationship between high-density lipoprotein cholesterol (HDL-C) and breast cancer has been studied, no consistent association has been explicitly confirmed. The aim of this study was to demonstrate the relationship between breast cancer and lipid profiles in Taiwanese women.

Methods: A total of 150 breast cancer patients before treatment and 71 healthy controls were enrolled. Lipid profiles in fasting serum were measured after participants gave their consent.

Results: The breast cancer patients had significantly lower values for HDL-C and apolipoprotein A-I (apoA-I), lower apoA-I/apoB ratios and higher values for very-low-density lipoprotein cholesterol (VLDL-C) than controls. After logistic regression analysis, the breast cancer patients had significantly higher values for VLDL-C and lower values for apoA-I after controlling for HDL-C and the apoA-I/apoB ratio.

Conclusions: Our findings demonstrate that higher VLDL-C and lower apoA-I values were significantly associated with breast cancer, with a greater association between apoA-I values and the development of breast cancer than for HDL-C values.

Clin Chem Lab Med 2007;45:1219–23.

Keywords: apolipoprotein; breast cancer; lipid profiles; very-low-density lipoprotein cholesterol

About the article

Corresponding author: Professor Li-Yu Tsai, PhD, Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan Phone: +886-7-3121101-2350, Fax: +886-7-2370544,


Received: 2007-03-20

Accepted: 2007-05-21

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.263.

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