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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 45, Issue 9


Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects

Abayomi O. Akanji / Jude U. Ohaeri / Suhail A. Al-Shammri / Hasmukh R. Fatania
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.265


Background: Insulin-like growth factors (IGFs) are believed to be important in brain development and repair following neuronal damage. It is also speculated that IGFs are involved in the association of foetal and pre-adult growth with schizophrenia (SZ).

Methods: The aim of this study was to assess levels of IGF-I, IGF-II and IGF binding protein (IGFBP)-3 and their associations in male Arab patients with SZ (n=53) and healthy control subjects (HC; n=52). Anthropometric and demographic data were collected for each subject for whom blood specimens were analysed for serum lipoproteins, apolipoprotein B (apoB), IGF-I, IGF-II and IGFBP-3.

Results: The SZ group had lower serum total cholesterol, apoB and uric acid levels than the HC group (p<0.05). IGF-II levels were significantly higher in the SZ group (p=0.02) and correlated positively with levels of atherogenic lipoproteins – total cholesterol, low-density lipoprotein, apoB – and IGFBP-3. The pattern of correlations between the IGFs and the various parameters differed somewhat between the HC and SZ groups.

Conclusions: These results demonstrate that IGF-II levels are increased in patients with SZ and show significant associations with atherogenic lipoproteins. We suggest a possible link between IGF-II metabolism and atherogenesis in SZ.

Clin Chem Lab Med 2007;45:1229–31.

Keywords: Arabs; atherogenic dyslipidaemia; insulin-like growth factor-I (IGF-I); IGF-II; insulin-like growth factor-binding protein (IGFBP); schizophrenia

About the article

Corresponding author: Professor Abayomi Akanji, Clinical Chemistry Unit, Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait Phone: +965-531-9476, Fax: +965-533-8905,

Received: 2007-01-29

Accepted: 2007-05-21

Published Online: 2007-09-11

Published in Print: 2007-09-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1229–1231, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.265.

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