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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
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1437-4331
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Volume 45, Issue 9

Issues

Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study

Simonetta Palleschi
  • 1Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sandro De Angelis / Loretta Diana
  • 3Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Barbara Rossi
  • 4Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Vincenza Papa
  • 5Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Giancarlo Severini
  • 6Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
  • Other articles by this author:
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/ Giorgio Splendiani
Published Online: 2007-09-11 | DOI: https://doi.org/10.1515/CCLM.2007.266

Abstract

Background: Oxidative stress (OS) is considered to play a major role in the development of end-stage renal disease (ESRD) complications. However, conflicting and inconsistent data have been reported on OS in ESRD patients. Our aim was to investigate the reliability of the most popular non-enzymatic plasma OS biomarkers in ESRD.

Methods: Vitamins A (VitA), E and C (VitC), uric acid, plasma antioxidant and ferric-reducing potential (PAP and PRP), thiols (SH), malondialdehyde (MDA) and lipid hydroperoxides (HPO) were determined before and after dialysis in plasma from 33 ESRD patients on hemodialysis, hemodiafiltration or peritoneal dialysis and 20 control subjects.

Results: In ESRD patients, high PRP and normal PAP values were positively correlated with VitC levels. After dialysis, PRP levels decreased, while unchanged PAP levels correlated positively with high VitA and transiently recovered SH values. All patients showed high levels of both MDA and cholesterol-normalized HPO. However, while the former significantly decreased after dialysis, the latter were unaffected by treatment. Paradoxical correlations of MDA with both VitA and HPO were found.

Conclusions: Plasma PRP and MDA levels may be dramatically affected by both uremia and dialysis; their use in ESRD patients may therefore lead to OS misevaluation and should be avoided. More reliable results can be obtained using physiologically relevant OS functional tests, such as PAP, and early biomarkers of OS damage, such as SH and HPO.

Clin Chem Lab Med 2007;45:1211–8.

Keywords: antioxidants; chronic kidney failure; lipid peroxides; malondialdehyde; oxidative stress; renal dialysis; vitamins

About the article

Corresponding author: Simonetta Palleschi, PhD, Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy Phone: +39-06-49902776, Fax: +39-06-49902757,


Received: 2007-03-05

Accepted: 2007-05-21

Published Online: 2007-09-11

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1211–1218, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.266.

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