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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 45, Issue 9

Issues

Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review

Cynthia M. Balion
  • 1Department of Laboratory Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Parminder S. Raina
  • 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada and McMaster University Evidence-based Practice Center, McMaster University, Hamilton, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hertzel C. Gerstein
  • 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ P. Lina Santaguida
  • 4Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada and McMaster University Evidence-based Practice Center, McMaster University, Hamilton, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Katherine M. Morrison / Lynda Booker
  • 6Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada and McMaster University Evidence-based Practice Center, McMaster University, Hamilton, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dereck L. Hunt

Abstract

Background: The classifications of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) represent glucose levels above normal, but below the decision threshold for diabetes. We sought to determine what the reproducibility of these classifications was when repeat tests were performed by conducting a systematic review of the literature.

Methods: All primary studies published in English of any study design were included. Studies were excluded if they did not follow the World Health Organization or American Diabetes Association diagnostic criteria, used whole blood as the specimen type, a glucose meter for analysis, or performed repeat testing greater than 8 weeks apart.

Results: Five papers had reproducibility data for IGT or IFG, two of which where from the same population but sampled differently. The κ coefficients, indicating agreement between repeat tests that exceeded chance, indicated poor to fair agreement for IGT (0.04, 0.22, 0.38, 0.42) and moderate agreement for IFG (0.44 and 0.56). Similarly, the observed reproducibility was slightly lower for IGT (33%, 44%, 47%, 48%) compared to IFG (51%, 64%). In two studies for which data were available for both IGT and IFG, the average reproducibility was lower (49%) for the prediabetes group compared to the diabetes group (73%) or the normal group (93%).

Conclusions: Poor reproducibility of IGT and IFG classification suggests caution should be exercised when interpreting a single test result.

Clin Chem Lab Med 2007;45:1180–5.

Keywords: classification; diagnosis; impaired fasting glucose; impaired glucose tolerance; reproducibility; systematic review

About the article

Corresponding author: Dr. Cynthia Balion, Department of Laboratory Medicine, Hamilton General Hospital, 237 Barton St. E. Hamilton, Ontario, Canada L8L 2X2 Phone: +1-905-5274322 ext. 46120, Fax: +1-905-5778027,


Received: 2007-03-07

Accepted: 2007-05-14

Published in Print: 2007-09-01


Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 9, Pages 1180–1185, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.505.

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