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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 46, Issue 1 (Jan 2008)

Issues

Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics

Mika Ala-Korpela
  • 1Laboratory of Computational Engineering, Systems Biology and Bioinformation Technology, Helsinki University of Technology, Espoo, Finland
  • Other articles by this author:
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Published Online: 2007-11-18 | DOI: https://doi.org/10.1515/CCLM.2008.006

Abstract

This review focuses on (i) the current status of 1H NMR spectroscopy to quantify lipoprotein subclasses directly from serum or plasma, and (ii) the applications of 1H NMR metabonomics of serum in biomedicine. Related to both themes, experimental and data analysis methodologies are discussed together with the biochemical rationales. Particular emphasis is placed on the concepts of risk assessment and diagnostics in relation to the potential clinical role of 1H NMR metabonomics; recent applications in the area of coronary heart disease and diabetes are addressed in more detail.

Clin Chem Lab Med 2008;46:27–42.

Keywords: blood plasma and serum; coronary heart disease; data analysis; diagnostics; lipoprotein subclass; metabolomics; metabonomics; nuclear magnetic resonance spectroscopy; quantification; risk assessment

About the article

Corresponding author: Dr. Mika Ala-Korpela, PhD in Physics, Docent in Biological NMR, Group Leader in Computational Medicine, Laboratory of Computational Engineering, Systems Biology and Bioinformation Technology, Helsinki University of Technology, P.O. Box 9203, 02015 HUT Finland Phone: +358-50-3535457, Fax: +358-9-4514833,


Received: 2007-07-05

Accepted: 2007-08-06

Published Online: 2007-11-18

Published in Print: 2008-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.006.

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