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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
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1437-4331
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Lipid peroxidation in stroke patients

Gianna Ferretti1 / Tiziana Bacchetti2 / Simona Masciangelo3 / Laura Nanetti4 / Laura Mazzanti5 / Mauro Silvestrini6 / Marco Bartolini7 / Leandro Provinciali8

1Istituto di Biochimica, Università Politecnica delle Marche, Ancona, Italy

2Istituto di Biochimica, Università Politecnica delle Marche, Ancona, Italy

3Istituto di Biochimica, Università Politecnica delle Marche, Ancona, Italy

4Istituto di Biochimica, Università Politecnica delle Marche, Ancona, Italy

5Istituto di Biochimica, Università Politecnica delle Marche, Ancona, Italy

6Clinica Neurologica, Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy

7Clinica Neurologica, Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy

8Clinica Neurologica, Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy

Corresponding author: Tiziana Bacchetti, Istituto di Biochimica, Università Politecnica delle Marche Via Ranieri, 60131, Ancona, Italy Phone: +39-07-12204968, Fax: +39-07-12204398,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 1, Pages 113–117, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.011, November 2007

Publication History

Received:
2007-06-18
Accepted:
2007-07-31
Published Online:
2007-11-22

Abstract

Background: Paraoxonase is high-density lipoprotein (HDL)-associated esterase/lactonase implicated to play a role in the antioxidant and anti-inflammatory properties exerted by HDL. Increasing evidence support a role of free radicals and oxidative stress in neuronal damage induced by ischemia-reperfusion. The aim of this study was to further investigate the relationship between lipoprotein oxidative damage and stroke.

Methods: We compared the paraoxonase activity and levels of lipid hydroperoxides in plasma isolated from healthy subjects (n=50) and from stroke patients (n=49). Moreover, the correlations between biochemical markers and the National Institute of Health Stroke Scale (NIHSS), which is widely used to study neurological severity, were evaluated.

Results: Our results demonstrated, for the first time, that the activity of paraoxonase in plasma of stroke subjects was significantly lower than controls (p<0.001) and the levels of lipid hydroperoxides were significantly higher in plasma from patients (p<0.001). Moreover, using linear regression analysis, significant correlations between the activity of paraoxonase, lipid peroxidation and the severity of neurological deficit at admission were observed.

Conclusions: These results provide further evidence that oxidative stress and impairment of the antioxidant system may play a role in stroke. Antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.

Clin Chem Lab Med 2008;46:113–7.

Keywords: antioxidants; lipid peroxidation; lipoproteins; paraoxonase; stroke

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