Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 46, Issue 11

Issues

Troponin revisited 2008: assay performance

Jillian R. Tate
  • 1Department of Chemical Pathology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-10-09 | DOI: https://doi.org/10.1515/CCLM.2008.292

Abstract

Troponin quality specifications describing the pre-analytical, analytical and post-analytical performance of cardiac troponin (cTn) assays are important for both manufacturers of cTn assays and laboratories that routinely test for cTn. Pre-analytical requirements refer not only to acceptable sample type for analysis and the stability of cTn but also to the proper handling of specimens prior to analysis to avoid pre-analytical false positive results. Analytical issues that may contribute to differences between cTn assays include analytical sensitivity and imprecision at low cTn concentration, antibody specificity and immunoreactivity of plasma cTn forms, assay specificity and the presence of falsely positive and negative interferences, and for cTnI the lack of standardised measurement, all which may impact on patient cTn results. Current second generation cTnI and fourth generation cTnT assays generally have an imprecision of around 20% coefficient of variation (CV) at the 99th percentile of the reference population, which is greater than the recommended imprecision of 10% CV. As the next generation of more analytically sensitive cTn assays are developed it can be anticipated that cTn upper reference limits will decrease by approximately 10-fold. Monitoring assay imprecision at ultra low cTn concentrations will require that the laboratory uses a quality control close to this level and a negative control to monitor baseline drift. Establishment of cTn reference ranges will require reference populations to be cardio-healthy to enable differentiation from community populations who are at increased cardiovascular risk. Close collaboration between the laboratory and local clinicians is required to ensure adequate clinical validation of more sensitive cTn assays.

Clin Chem Lab Med 2008;46:1489–500.

Keywords: acute coronary syndromes; cardiac troponin; 99th percentile; pre-analytical; quality specifications

About the article

Corresponding author: Jillian Tate, Department of Chemical Pathology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia Phone: +61-7-3636-3441, Fax: +61-7-3636-3417,


Received: 2008-06-13

Accepted: 2008-08-18

Published Online: 2008-10-09

Published in Print: 2008-11-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 11, Pages 1489–1500, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.292.

Export Citation

©2008 by Walter de Gruyter Berlin New York.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jacobus P J Ungerer, Louise Marquart, Peter K O'Rourke, Urs Wilgen, and Carel J Pretorius
Clinical Chemistry, 2012, Volume 58, Number 1, Page 274
[3]
Oleksiy Krupin and Pierre Berini
Sensors, 2019, Volume 19, Number 3, Page 631
[4]
Peter J Selby, Rosamonde E Banks, Walter Gregory, Jenny Hewison, William Rosenberg, Douglas G Altman, Jonathan J Deeks, Christopher McCabe, Julie Parkes, Catharine Sturgeon, Douglas Thompson, Maureen Twiddy, Janine Bestall, Joan Bedlington, Tilly Hale, Jacqueline Dinnes, Marc Jones, Andrew Lewington, Michael P Messenger, Vicky Napp, Alice Sitch, Sudeep Tanwar, Naveen S Vasudev, Paul Baxter, Sue Bell, David A Cairns, Nicola Calder, Neil Corrigan, Francesco Del Galdo, Peter Heudtlass, Nick Hornigold, Claire Hulme, Michelle Hutchinson, Carys Lippiatt, Tobias Livingstone, Roberta Longo, Matthew Potton, Stephanie Roberts, Sheryl Sim, Sebastian Trainor, Matthew Welberry Smith, James Neuberger, Douglas Thorburn, Paul Richardson, John Christie, Neil Sheerin, William McKane, Paul Gibbs, Anusha Edwards, Naeem Soomro, Adebanji Adeyoju, Grant D Stewart, and David Hrouda
Programme Grants for Applied Research, 2018, Volume 6, Number 3, Page 1
[5]
Peter E. Hickman, Gus Koerbin, Tony Badrick, Carmen Oakman, and Julia M. Potter
Clinical Biochemistry, 2018
[6]
Mark Mariathas, Bartosz Olechowski, Michael Mahmoudi, and Nick Curzen
Expert Review of Cardiovascular Therapy, 2017, Page 1
[7]
Clementine YF Yap, Soon Kieng Phua, and Tar Choon Aw
Proceedings of Singapore Healthcare, 2012, Volume 21, Number 2, Page 153
[8]
Hua Jiang, Jiapin Zhu, Wenwei Liu, and Fengsheng Cao
Frontiers in Laboratory Medicine, 2017
[10]
William A. Parsonage, Jillian R. Tate, Jaimi H. Greenslade, Christopher J. Hammett, Jacobus P.J. Ungerer, Carel J. Pretorius, Anthony F.T. Brown, and Louise Cullen
Clinical Chemistry and Laboratory Medicine (CCLM), 2014, Volume 52, Number 2
[11]
W.-J. Li, X.-M. Chen, X.-Y. Nie, X.-X. Lin, Y.-J. Cheng, C.-H. Hu, Z.-M. Du, Y.-G. Dong, H. Ma, and S.-H. Wu
Internal Medicine Journal, 2015, Volume 45, Number 7, Page 748
[12]
Sally Aldous, John Elliott, Dougal McClean, Aniket Puri, and A. Mark Richards
Heart, Lung and Circulation, 2015, Volume 24, Number 9, Page 869
[14]
Kai M. Eggers, Sally Aldous, Jaimi H. Greenslade, Nina Johnston, Bertil Lindahl, William A. Parsonage, John W. Pickering, Martin Than, and Louise Cullen
Clinica Chimica Acta, 2015, Volume 445, Page 19
[15]
Josef Horak, Can Dincer, Edvina Qelibari, Hüseyin Bakirci, and Gerald Urban
Sensors and Actuators B: Chemical, 2015, Volume 209, Page 478
[16]
Jan FC Glatz and Reinhard Renneberg
Clinical Lipidology, 2014, Volume 9, Number 2, Page 205
[17]
A. Al-Saleh, A. Alazzoni, S. Al Shalash, C. Ye, L. Mbuagbaw, L. Thabane, and S. S. Jolly
CMAJ Open, 2014, Volume 2, Number 3, Page E199
[18]
Heidi Hyytiä, Taina Heikkilä, Eeva-Christine Brockmann, Henna Kekki, Pirjo Hedberg, Tarja Puolakanaho, Timo Lövgren, and Kim Pettersson
Clinical Biochemistry, 2015, Volume 48, Number 4-5, Page 347
[19]
Randolph L. Winter, Ashley B. Saunders, Sonya G. Gordon, Matthew W. Miller, Katharine T. Sykes, Jan S. Suchodolski, and Jörg M. Steiner
Journal of Veterinary Cardiology, 2014, Volume 16, Number 2, Page 81
[20]
Birgit Linnemann, Thilo Sutter, Eva Herrmann, Sebastian Sixt, Aljoscha Rastan, Uwe Schwarzwaelder, Elias Noory, Karlheinz Buergelin, Ulrich Beschorner, and Thomas Zeller
Journal of the American College of Cardiology, 2014, Volume 63, Number 15, Page 1529
[21]
A. L. C. Schneider, A. M. Rawlings, A. R. Sharrett, A. Alonso, T. H. Mosley, R. C. Hoogeveen, C. M. Ballantyne, R. F. Gottesman, and E. Selvin
European Heart Journal, 2014, Volume 35, Number 27, Page 1817
[22]
Satish K. Tuteja, Priyanka, Vijayender Bhalla, Akash Deep, A.K. Paul, and C. Raman Suri
Analytica Chimica Acta, 2014, Volume 809, Page 148
[23]
Gus Koerbin, Ken Andrew Sikaris, Graham Ross Dallas Jones, Julie Ryan, Maxine Reed, and Jill Tate
Clinica Chimica Acta, 2014, Volume 432, Page 99
[24]
Louise Cullen, William A. Parsonage, Jaimi Greenslade, Arvin Lamanna, Christopher J. Hammett, Martin Than, Jillian Tate, Lauren Kalinowski, Jacobus P.J. Ungerer, Kevin Chu, and Anthony Brown
International Journal of Cardiology, 2013, Volume 168, Number 3, Page 2602
[25]
Dimitrios Ntelios, Eleftheria Mpei, Eleftheria Gousi, Evangelos Potolidis, Panagiotis Fanourgiakis, and Charalampos Mandros
The American Journal of Emergency Medicine, 2013, Volume 31, Number 6, Page 997.e1
[26]
Fang Li, Yuqi Yu, Hua Cui, Di Yang, and Zhiping Bian
The Analyst, 2013, Volume 138, Number 6, Page 1844
[27]
J.-P. Bertinchant and A. Polge
EMC - Cardiologie, 2010, Volume 5, Number 4, Page 1
[28]
G. Lefèvre
Immuno-analyse & Biologie Spécialisée, 2012, Volume 27, Number 4, Page 205
[29]
Marja-Leena Järvenpää, Katri Kuningas, Ilari Niemi, Pirjo Hedberg, Noora Ristiniemi, Kim Pettersson, and Timo Lövgren
Clinica Chimica Acta, 2012, Volume 414, Page 70
[30]
Maria Lyck Hansen, Lotte Saaby, Mads Nybo, Lars Melholt Rasmussen, Kristian Thygesen, Hans Mickley, and Tina Svenstrup Poulsen
Cardiology, 2012, Volume 122, Number 4, Page 225
[31]
Claudeen K. F. Scott and William A. Suarez
Pediatric Emergency Care, 2012, Volume 28, Number 6, Page 558
[32]
P. J. Conroy, R. J. O'Kennedy, and S. Hearty
Protein Engineering Design and Selection, 2012, Volume 25, Number 6, Page 295
[33]
Gjin Ndrepepa, Siegmund Braun, Julinda Mehilli, K. Anette Birkmeier, Robert A. Byrne, Ilka Ott, Karin Hösl, Stefanie Schulz, Massimiliano Fusaro, Jürgen Pache, Jörg Hausleiter, Karl-Ludwig Laugwitz, Steffen Massberg, Melchior Seyfarth, Albert Schömig, and Adnan Kastrati
American Heart Journal, 2011, Volume 161, Number 1, Page 68
[34]
Ralph Tölg, Uwe Zeymer, Ralf Birkemeyer, Rainer Wessely, Holger Eggebrecht, Wolfgang Bocksch, Steffen Schneider, Gert Richardt, and Christian Hamm
Clinical Research in Cardiology, 2012, Volume 101, Number 9, Page 727
[35]
Gusheng Tang, Yu Wu, Weiguo Zhao, and Qian Shen
Clinical and Experimental Medicine, 2012, Volume 12, Number 1, Page 47
[36]
Tao Kong, Ruigong Su, Beibei Zhang, Qi Zhang, and Guosheng Cheng
Biosensors and Bioelectronics, 2012, Volume 34, Number 1, Page 267
[37]
Birgit Linnemann, Thilo Sutter, Sebastian Sixt, Aljoscha Rastan, Uwe Schwarzwaelder, Elias Noory, Karlheinz Buergelin, Ulrich Beschorner, and Thomas Zeller
Journal of Vascular Surgery, 2012, Volume 55, Number 3, Page 721
[38]
Guillaume Lefèvre and Thierry Laperche
Revue Francophone des Laboratoires, 2009, Volume 2009, Number 409, Page 51
[39]
Sally J. Aldous
International Journal of Cardiology, 2013, Volume 164, Number 3, Page 282
[41]
Till Keller, Tanja Zeller, Dirk Peetz, Stergios Tzikas, Alexander Roth, Ewa Czyz, Christoph Bickel, Stephan Baldus, Ascan Warnholtz, Meike Fröhlich, Christoph R. Sinning, Medea S. Eleftheriadis, Philipp S. Wild, Renate B. Schnabel, Edith Lubos, Nicole Jachmann, Sabine Genth-Zotz, Felix Post, Viviane Nicaud, Laurence Tiret, Karl J. Lackner, Thomas F. Münzel, and Stefan Blankenberg
New England Journal of Medicine, 2009, Volume 361, Number 9, Page 868
[42]
Liisa Petäjä, Markku Salmenperä, Kari Pulkki, and Ville Pettilä
The Annals of Thoracic Surgery, 2009, Volume 87, Number 6, Page 1981
[44]
Mauro Panteghini
Clinica Chimica Acta, 2009, Volume 402, Number 1-2, Page 88
[45]
Viroj Wiwanitkit
Injury, 2011, Volume 42, Number 9, Page 965
[46]
S. J. Aldous
Internal Medicine Journal, 2011, Volume 41, Number 7, Page 513
[47]
L. Kristin Newby, Ignacio Rodriguez, John Finkle, Richard C. Becker, Karen A. Hicks, Elizabeth Hausner, Ruth Chesler, Courtney Harper, Shari Targum, Brian R. Berridge, Eric Lewis, Dana B. Walker, Colin Dollery, J. Rick Turner, and Mitchell W. Krucoff
American Heart Journal, 2011, Volume 162, Number 1, Page 64
[48]
Giuseppe Lippi, Martina Montagnana, and Gian Cesare Guidi
The American Journal of Cardiology, 2009, Volume 103, Number 9, Page 1332
[49]
Md. Rajibul Akanda, Md. Abdul Aziz, Kyungmin Jo, Vellaiappillai Tamilavan, Myung Ho Hyun, Sinyoung Kim, and Haesik Yang
Analytical Chemistry, 2011, Volume 83, Number 10, Page 3926
[50]
Young-Chul Kwon, Min-Gon Kim, Eon-Mi Kim, Yong-Beom Shin, Seok-Ki Lee, Sung Dong Lee, Myung-Je Cho, and Hyeon-Su Ro
Biotechnology Letters, 2011, Volume 33, Number 5, Page 921
[51]
Jillian R. Tate, David M. Bunk, Robert H. Christenson, Alexei Katrukha, James E. Noble, Robert A. Porter, Heinz Schimmel, Lili Wang, and Mauro Panteghini
Pathology, 2010, Volume 42, Number 5, Page 402
[52]
Albrecht Pfäfflin
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 7
[53]
E. J. van den Bos, A. A. Constantinescu, R. T. van Domburg, S. Akin, L. J. Jordaens, and M. J. M. Kofflard
European Heart Journal, 2011, Volume 32, Number 5, Page 611
[54]
Karl J. Lackner
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 12
[55]
Feng Wang, Jianxin Wang, Zhiquan Zhang, Changjiang Sun, Yueguo Wang, Shaoqing Ju, and Huimin Wang
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 12
[56]
Aihong Li and Göran Brattsand
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 2
[57]
Alberto Giannoni, Stefania Giovannini, and Aldo Clerico
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 10
[58]
Giuseppe Lippi, Giovanni Targher, Massimo Franchini, and Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 10
[59]
James E. Noble, David M. Bunk, Robert H. Christenson, Kenneth D. Cole, Hua-Jun He, Alexei G. Katrukha, Mauro Panteghini, Robert A. Porter, Heinz Schimmel, Jillian R. Tate, and Lili Wang
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 11
[60]
Jonas Hallén and Dan Atar
Biomarkers in Medicine, 2010, Volume 4, Number 6, Page 889
[61]
K. Thygesen, J. Mair, H. Katus, M. Plebani, P. Venge, P. Collinson, B. Lindahl, E. Giannitsis, Y. Hasin, M. Galvani, M. Tubaro, J. S. Alpert, L. M. Biasucci, W. Koenig, C. Mueller, K. Huber, C. Hamm, and A. S. Jaffe
European Heart Journal, 2010, Volume 31, Number 18, Page 2197
[62]
Ferenc Hadarits, Andrea Iván, Csaba Márkus, and Lajos Nagy
Orvosi Hetilap, 2009, Volume 150, Number 43, Page 1988

Comments (0)

Please log in or register to comment.
Log in