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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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Volume 46, Issue 11 (Nov 2008)


Plasma homocysteine and vascular disease in elderly patients with mental illness

Karin Nilsson / Lars Gustafson / Björn Hultberg
  • 3Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University Hospital, Lund, Sweden
  • Other articles by this author:
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Published Online: 2008-10-09 | DOI: https://doi.org/10.1515/CCLM.2008.301


Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness compared to control subjects. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors, such as age and genetics. In this review, we summarize the findings of our investigations of vascular disease and plasma tHcy level in elderly patients with mental illness. Elevated plasma tHcy concentration in elderly patients with mental illness was mainly associated with the presence of vascular disease and was not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, serum N-terminal pro-brain natriuretic peptide, and serum C-reactive protein.

Clin Chem Lab Med 2008;46:1556–61.

Keywords: Alzheimer's disease; homocysteine; mental illness; vascular dementia; vascular disease

About the article

Corresponding author: Björn Hultberg, Institute of Laboratory Medicine, Department of Clinical Chemistry, Lund University Hospital, 22185 Lund, Sweden Phone: +46-46173447, Fax: +46-46189114,

Received: 2008-05-15

Accepted: 2008-06-19

Published Online: 2008-10-09

Published in Print: 2008-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.301.

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©2008 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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