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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 46, Issue 11 (Nov 2008)


Oxidative stress, free radicals and bone remodeling

Giuseppe Banfi
  • 1Laboratory of Cell Culture and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy and Department of Health Technology, University of Milan, Milan, Italy
/ Eugenio L. Iorio
  • 2International Observatory of Oxidative Stress, Salerno, Italy
/ Massimiliano M. Corsi
  • 3Institute of General Pathology, Laboratory of Clinical Pathology, University of Milan, Milan, Italy and Laboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Published Online: 2008-10-10 | DOI: https://doi.org/10.1515/CCLM.2008.302


Reactive oxygen species (ROS) are widely considered to be a causal factor in aging and in a number of pathological conditions, such as atherosclerosis, carcinogenesis and infarction. Their role in bone metabolism is dual, considering their effects under physiological or pathological conditions. Under physiological conditions, the production of ROS by osteoclasts helps accelerate destruction of calcified tissue, thus assisting in bone remodeling. In pathological conditions, when a bone fractures, e.g., radical generation is remarkably high. However, though the increases in osteoclastic activity and ROS production are linked in many skeletal pathologies, it remains to be clarified whether increased ROS production overwhelms antioxidant defenses, leaving the individual open to hyperoxidant stress.

Clin Chem Lab Med 2008;46:1550–5.

Keywords: bone metabolism; ethanol (EtOH); NADPH oxidase (Nox); nitric oxide (NO); osteoporosis; oxidized low-density lipoprotein (OxLDL); reactive oxygen species (ROS); tartrate-resistant acid phosphatase (TRACP)

About the article

Corresponding author: Prof. Massimiliano M. Corsi, MD, PhD, Institute of General Pathology, Laboratory of Clinical Pathology, Medical Faculty, University of Milan, 20133, Milan, Italy

Received: 2008-05-09

Accepted: 2008-06-26

Published Online: 2008-10-10

Published in Print: 2008-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.302. Export Citation

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