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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 46, Issue 2 (Feb 2008)

Issues

Probing the redox activity of T-lymphocytes deposited at electrode surfaces with voltammetric methods

Ivan Bogeski / Valentin Mirčeski
  • 2Institute of Chemistry Faculty of Natural Sciences and Mathematics, “Sv Kiril i Metodij” University, Skopje, Republic of Macedonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Markus Hoth
Published Online: 2007-12-13 | DOI: https://doi.org/10.1515/CCLM.2008.023

Abstract

Background: Reactive oxygen species and redox signaling play an important role in the regulation of many vital biological processes. However, they are also tightly connected with many pathological conditions. The detection and evaluation of these signaling events are very often accompanied with great difficulties. In this article, we describe the development of a novel electrochemically-based technique for monitoring the cellular redox state.

Methods and results: T-cells were attached on the surface of a working electrode, which was modified with 2-palmitoylhydroquinone as a redox mediator. Using cyclic voltammetry, we were able to indirectly (via the redox mediator) monitor an electron transport from the cells towards the working electrode, which enabled us to evaluate the redox activity of the cells.

Conclusions: This new technique is rather simple and sensitive and may be used in the future as a valid diagnostic procedure in various branches of biomedical science.

Clin Chem Lab Med 2008;46:197–203.

Keywords: reactive oxygen species; redox signaling; T-cell; transmembrane electron-transfer; voltammetry

About the article

Corresponding author: Ivan Bogeski, Department of Physiology, Saarland University, Homburg, Germany Phone: +49-6841-16-26452, Fax: +49-6841-16-26060


Received: 2007-07-14

Accepted: 2007-09-06

Published Online: 2007-12-13

Published in Print: 2008-02-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2008.023.

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©2008 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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