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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Serum levels of the osteoprotegerin, receptor activator of nuclear factor κ-B ligand, metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 levels are increased in men 6 months after acute myocardial infarction

Antonios Halapas
  • 1Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece and Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Achilleas Zacharoulis
  • 2Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Stamatios Theocharis
  • 3Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
/ Apostolos Karavidas
  • 4Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Dimitrios Korres
  • 5Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Kostantinos Papadopoulos
  • 6Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Harris Katopodis
  • 7Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
/ Anastasia Stavropoulou
  • 8Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
/ Peter Lembessis
  • 9Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
/ Costas Xiromeritis
  • 10Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
/ Apostolos Zacharoulis
  • 11Department of Cardiology, General Hospital G. Genimmatas, Athens, Greece
/ Michael Koutsilieris
  • 12Department of Experimental Physiology, Medical School, University of Athens, Athens, Greece
Published Online: 2008-02-26 | DOI: https://doi.org/10.1515/CCLM.2008.091

Abstract

Background: Osteoprotegerin (OPG) and receptor activator of nuclear factor κ-B ligand (RANKL) are critical regulators of bone remodeling and RANKL/RANK signaling could also play an important role in the remodeling process of several tissues, such as myocardium. Therefore, we investigated whether the serum concentrations of OPG and RANKL correlate with the serum levels of metalloproteinase-1 (MMP-1), MMP-9 and tissue inhibitors of MMP-1 (TIMP-1), which are known regulators of myocardial healing in acute myocardial infarction (AMI) patients.

Methods: We analyzed blood samples from 51 consecutively hospitalized men with AMI, 12 men with established ischemic heart failure (New York Heart Association category II, NYHA-II) and 12 healthy men age-matched to the NYHA-II patients. Serum levels of MMP-1, MMP-9, TIMP-1, OPG and RANKL were quantified using commercially available ELISA kits. AMI patients were sampled 4 days and 6 months after MI.

Results: Our data revealed increased serum levels of OPG, RANKL, MMP-1 and TIMP-1 levels and significant correlations between increased RANKL levels and MMP-1 and TIMP-1 serum levels 6 months after MI. In addition, the ratio OPG/RANKL was very low 6 months after MI, suggesting that the nuclear factor κ-B signaling is possibly more active 6 months post-MI than it is on day 4 post-MI.

Conclusions: Our data suggest that OPG, RANKL, MMP-1 and TIMP-1 serum levels can be potential mediators of myocardial healing after MI. However, further large studies are needed to confirm the utility of OPG and RANKL as markers of healing after ST elevation in MI.

Clin Chem Lab Med 2008;46:510–6.

Keywords: extracellular matrix; matrix metalloproteinases; myocardial infarction; osteoprotegerin; receptor activator of nuclear factor κ-B ligand; tissue inhibitors of metalloproteinase

Corresponding author: Michael Koutsilieris, MD, PhD, Professor and Director, Department of Experimental Physiology, Medical School, University of Athens, 75 Micras Asias Goudi, Athens, 115 27 Greece Phone: +30-210-7462597, Fax: +30-210-7462571,


Received: 2007-09-25

Accepted: 2007-12-08

Published Online: 2008-02-26

Published in Print: 2008-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 4, Pages 510–516, ISSN (Online) 14374331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.091, February 2008

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