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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

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Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 46, Issue 4 (Apr 2008)

Issues

Reference intervals for circulating angiogenic cytokines

Sun-Young Kong
  • 1Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
  • Other articles by this author:
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/ Hye Lin Lee
  • 2Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Hyeon-Seok Eom
  • 3Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
  • Other articles by this author:
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/ Weon-Seo Park
  • 4Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Tak Yun
  • 5Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Hyun-Ju Kim
  • 6Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Byung-Ho Nam
  • 7Cancer Registration and Biostatistics Branch, Division of Cancer Prevention, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Moon-Woo Seong
  • 8Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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/ Do-Hoon Lee
  • 9Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea
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Published Online: 2008-02-26 | DOI: https://doi.org/10.1515/CCLM.2008.092

Abstract

Background: The levels of angiogenic cytokines are important in the definition of baseline characteristics of cancers and to predict patient prognosis; however, the reference intervals for angiogenic cytokines have received only limited attention. Herein, we obtained reference intervals for angiogenic cytokines, including vascular endothelial growth factor (VEGF), hepatocyte growth factor, basic fibroblast growth factor, interleukin-6, vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2.

Methods: We measured these materials in serum, plasma and urine of 131 controls, according to the guidelines of the Clinical and Laboratory Standards Institute. We analyzed the association between angiogenic cytokine levels and other laboratory parameters and explored whether polymorphisms in angiogenic cytokine genes affect the levels of cytokines.

Results/Conclusions: These data allowed us to construct reference intervals for angiogenic cytokines, and we also observed that concentrations of angiogenic cytokines generally do not vary with genotype or haplotype. An exception was serum VEGF concentration; this level was marginally affected by the –1154 VEGF polymorphism.

Clin Chem Lab Med 2008;46:545–50.

Keywords: angiogenic cytokine; reference interval

About the article

Corresponding author: Sun-Young Kong, MD, PhD, Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea Phone: +82-31-920-1735, Fax: +82-31-920-1738,


Received: 2007-10-01

Accepted: 2007-12-01

Published Online: 2008-02-26

Published in Print: 2008-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 14374331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.092.

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©2008 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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