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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 46, Issue 4

Issues

Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese

Bernard M.Y. Cheung / Kwok Leung Ong / Roberta V. Cheung / Louisa Y.F. Wong / Nelson M.S. Wat / Sidney Tam / Gabriel M. Leung / Chun Ho Cheng / Jean Woo / Edward D. Janus / Chu Pak Lau / Tai Hing Lam / Karen S.L. Lam

Abstract

Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population.

Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort.

Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels.

Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.

Clin Chem Lab Med 2008;46:523–7.

Keywords: alkaline phosphatase; C-reactive protein; inflammation; liver

About the article

Corresponding author: Prof. Bernard M.Y. Cheung, Department of Clinical Pharmacology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Vincent Drive, Birmingham B15 2TH, UK Phone: +44-121-4146874, Fax: +44-121-4141355,


Received: 2007-10-15

Accepted: 2008-01-02

Published in Print: 2008-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 4, Pages 523–527, ISSN (Online) 14374331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.111.

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