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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
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1437-4331
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Volume 46, Issue 6

Issues

Antioxidant defense capacity in scleroderma patients

Roxana Sfrent-Cornateanu
  • 1Department of Physiopathology and Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Other articles by this author:
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/ Carina Mihai
  • 2Department of Internal Medicine and Rheumatology, Dr. I. Cantacuzino Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Irina Stoian
  • 3Department of Biochemistry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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/ Daniela Lixandru
  • 4Department of Biochemistry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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/ Constantin Bara
  • 5Department of Physiopathology and Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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/ Elena Moldoveanu
  • 6Department of Physiopathology and Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania and Ultrastructural Pathology Department, “Victor Babes” National Institute of Pathology, Bucharest, Romania
  • Other articles by this author:
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Abstract

Background: Oxidative stress is associated with scleroderma (systemic sclerosis) and is supposed to favor disease progression by complex effects on the vascular endothelium and on fibroblasts.

Methods: Plasma oxidative process marker, thiobarbituric acid-reactive substances, and several markers of antioxidant defense capacity (plasma total antioxidant activity, serum albumin, uric acid and glutathione, superoxide dismutase and catalase) were evaluated by spectrophotometric methods using blood samples collected from 23 scleroderma patients and 21 healthy controls.

Results: In scleroderma patients, thiobarbituric acid-reactive substances levels (mmol/L plasma) were significantly elevated (29.3±5.8) compared with healthy controls (16.6±3.1, p<0.001). Total antioxidant activity (mmol Trolox/L) was significantly lower in scleroderma patients than in controls (1.29±0.13 vs. 1.55±0.23, p<0.001), as well as the antioxidant gap (mmol Trolox/L) (0.57±0.18 vs. 0.92±0.22, p<0.001). Superoxide dismutase activity (IU/g hemoglobin) was markedly decreased in patients as compared with controls (395±184 vs. 659±211, p<0.001).

Conclusions: Lower plasma total antioxidant activity and plasma antioxidant gap in scleroderma patients show that plasma antioxidant defense is deficient in scleroderma patients. As previous studies on this issue are controversial, the decreased erythrocyte superoxide dismutase activity found in the patients in this study needs further investigation.

Clin Chem Lab Med 2008;46:836–41.

Keywords: antioxidant defense; oxidative stress; scleroderma; superoxide dismutase (SOD); systemic sclerosis

About the article

Corresponding author: Professor Elena Moldoveanu, PhD, Ultrastructural Pathology Department, “Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 76201 Buchrest, Romania Fax: +404-214115105,


Received: 2007-09-12

Accepted: 2008-01-28

Published in Print: 2008-06-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 6, Pages 836–841, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.132.

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