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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 46, Issue 6

Issues

Gender-modulated impact of apolipoprotein A5 gene (APOA5) −1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults

Evrim Komurcu-Bayrak
  • 1Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
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/ Altan Onat
  • 2Emeritus, Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
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/ Mehves Poda
  • 3Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
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/ Steve E. Humphries
  • 4Center for Cardiovascular Genetics, Royal Free and University College London (UCL) Medical School, Rayne Institute, London, UK
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/ Jutta Palmen
  • 5Center for Cardiovascular Genetics, Royal Free and University College London (UCL) Medical School, Rayne Institute, London, UK
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/ Filiz Guclu
  • 6Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
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/ Gunay Can
  • 7Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
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/ Nihan Erginel-Unaltuna
  • 8Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
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Abstract

Background: Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 −1131T>C and c.56C>G polymorphisms [single nucleotide polymorphism (SNP)] with serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] and the risk for metabolic syndrome (MS) in the Turkish Adult Risk Factor study.

Methods: We genotyped SNPs using the Taqman allelic discrimination assays in 1564 Turkish adults (51.4% female, mean age 54.1±11.6 years). MS and dyslipidemia were defined using the criteria of the National Cholesterol Education Program.

Results: For both SNPs, rare allele carriers had significantly higher fasting triglyceride levels in both genders, except the c.56G allele in men. The −1131C allele was associated with lower HDL cholesterol (HDL-C) levels in women. In relation to dyslipidemia, the c.56C>G and haplotype 1 had significant gender-genotype interactions (p<0.05). Otherwise, both SNPs were significantly associated with dyslipidemia after adjustment for risk factors in women. After similar adjustment, non-carriers of the haplotype 1 (odds ratio=4.1, p=0.003) increased the MS risk in women. However, no significant associations emerged between SNPs and HDL-C, dyslipidemia or MS in a similar analysis in men.

Conclusions: Excess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women.

Clin Chem Lab Med 2008;46:778–84.

Keywords: APOA5 polymorphisms; dyslipidemia; lipids; metabolic syndrome; Turkish population

About the article

Corresponding author: Nihan Erginel-Unaltuna, PhD, Department of Genetics, Institute for Experimental Medicine, Istanbul University, Vakif Gureba Cad. 34080 Sehremini, Istanbul, Turkey Phone: +90-212-4142200-33324, Fax: +90-212-5324171,


Received: 2008-01-07

Accepted: 2008-02-19

Published in Print: 2008-06-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 6, Pages 778–784, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.161.

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