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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

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Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 46, Issue 6


Distribution of plasma cardiac troponin I values in healthy subjects: pathophysiological considerations

Aldo Clerico
  • 1Fondazione Gabriele Monasterio and CNR Institute of Clinical Physiology, Pisa, Italy and Scuola Superiore S. Anna, Pisa, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonio Fortunato / Andrea Ripoli / Concetta Prontera / Gian Carlo Zucchelli / Michele Emdin


Background: The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method (Siemens Medical Solutions Diagnostics SrL) in healthy subjects and to characterize its relation to gender, age, as well as to N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP).

Methods: A Caucasian population of 692 healthy subjects (311 males and 381 females) with a mean (SD) age of 45.3 (17.3) years [range 11–89 years; females 46.5 (17.3) years, males 43.8 (17.1) years] was enrolled. The presence of cardiac or systemic acute or chronic diseases was excluded by history and accurate clinical evaluation.

Results: A significant difference was found between the cTnI values in men and women (men: median 0.012 μg/L, range from undetectable values to 0.196 μg/L; women: median 0.008 μg/L, range from undetectable values to 0.130 μg/L; p<0.0001 by Mann-Whitney U-test). When a multiple regression analysis was performed, NT-proBNP, gender and age significantly contributed to the regression with cTnI (R=0.444, p<0.0001).

Conclusions: Our data indicate that cut-off values, based on the 99th percentile of cTnI distribution in apparently healthy subjects, can significantly vary according to age and gender of the reference population.

Clin Chem Lab Med 2008;46:804–8.

Keywords: acute coronary syndrome; age; cardiac troponin I (cTnI); gender; N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP); reference interval; troponin assay

About the article

Corresponding author: Prof. Aldo Clerico, MD, Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Via Trieste 41, 56126 Pisa, Italy Phone: +39-0585-493569, Fax: +39-0585-493601,

Received: 2008-01-10

Accepted: 2008-02-19

Published in Print: 2008-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 6, Pages 804–808, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.162.

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