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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
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1437-4331
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Volume 46, Issue 6

Issues

Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome

Ferah Armutcu
  • 1Department of Biochemistry, Canakkale Onsekiz Mart University Medical Faculty, Canakkale, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Meryem Ataymen / Hulusi Atmaca / Ahmet Gurel

Abstract

Background: The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease.

Methods: A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects.

Results: Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p<0.01, p<0.05 and p<0.001, respectively) and xanthine oxidase activity were significantly higher (p<0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p<0.01 and p<0.05, respectively) in serum of the patients.

Conclusions: These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome.

Clin Chem Lab Med 2008;46:785–90.

Keywords: carbonyl protein; C-reactive protein; heat shock protein 70; metabolic syndrome; oxidative stress

About the article

Corresponding author: Dr. Ferah Armutcu, Department of Biochemistry, Canakkale Onsekiz Mart University Medical Faculty, 17100 Canakkale, Turkey Phone: +90-286-2180018 (1997), Fax: +90-286-2180393, ,


Received: 2007-11-29

Accepted: 2008-02-14

Published in Print: 2008-06-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 6, Pages 785–790, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.166.

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