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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

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1437-4331
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Volume 46, Issue 7

Issues

The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status

Hüsamettin Erdamar / Hüseyin Demirci
  • 2Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Halil Yaman / M. Kemal Erbil / Tolga Yakar / Banu Sancak / Sehri Elbeg / Gürsel Biberoğlu / İlhan Yetkin
  • 9Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-05-22 | DOI: https://doi.org/10.1515/CCLM.2008.183

Abstract

Background: Free radical-mediated oxidative stress has been implicated in the etiopathogenesis of several autoimmune disorders. Also, there is growing evidence supporting the role of reactive oxygen species in the pathogenesis of thyroid disorders. The aim of this study was to investigate the influence of hypothyroidism, hyperthyroidism, and their treatments on the metabolic state of oxidative stress, and antioxidant status markers.

Methods: A total of 20 newly diagnosed patients with overt hypothyroidism due to Hashimoto's thyroiditis, 20 patients with overt hyperthyroidism due to Graves' disease, and 20 healthy subjects as the control group were enrolled in the study. Fasting blood samples (12 h), taken at the initiation, after the 30th and 60th day of therapy were analyzed for malondialdehyde, nitrite, vitamin E, vitamin A, β-carotene, ascorbate, and myeloperoxidase and superoxide dismutase activity. No patient presented additional risk factors for increased reactive oxygen species levels.

Results: Malondialdehyde, nitrite, vitamin E, and myeloperoxidase activity increased in patients with hypothyroidism. After 2 months, the levels of nitrite and vitamin E were reduced to control levels by treatment. The patients with hyperthyroidism had increased levels of malondialdehyde and myeloperoxidase activity in comparison with the controls. Treatment with propylthiouracil attenuated these increments after 1 month.

Conclusions: Our results reveal an increased generation of reactive oxygen species and impairment of the antioxidant system in patients with hyperthyroidism, and particularly in patients with hypothyroidism. These findings indicate that thyroid hormones have a strong impact on oxidative stress and the antioxidant system.

Clin Chem Lab Med 2008;46:1004–10.

Keywords: antioxidant status; hyperthyroidism; hypothyroidism; oxidative stress

About the article

Corresponding author: Hüsamettin Erdamar, MD, Department of Medical Biochemistry, Tunceli Government Hospital, Tunceli, Turkey Phone: +90-428-2132700, Fax: +90-428-2122089,


Received: 2008-02-05

Accepted: 2008-03-06

Published Online: 2008-05-22

Published in Print: 2008-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 7, Pages 1004–1010, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.183.

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