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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 46, Issue 7


A comparison of two different assays for determining S-100B in serum and urine

Magnus Hallén / Rickard Carlhed / Mathias Karlsson / Thomas Hallgren / Mikael Bergenheim


Background: Brain injury after head trauma can be detected by S-100B measurements in serum. Recent preliminary studies indicate that urinary levels of S-100B are also increased after head injury, a finding that is of possible clinical value. The aims of the present study are two-fold: to compare serum measurements of two assays, the Liaison Sangtec®100 system and the Elecsys®S100 test, and to investigate to what extent they can detect and measure S-100B in urine.

Methods: A total of 191 serum and 174 urine samples from 107 patients (children aged between 1 and 18 years following head trauma) were measured with both assays. The results were compared using correlation analysis and Bland-Altman difference plots.

Results: Serum values of the Sangtec® system ranged from 0.02 to 2.28 μg/L, and from 0.005 to 2.13 μg/L for the Elecsys® test. Comparisons showed a clear correlation (correlation coefficient 0.80) but not an agreement between the methods. The Sangtec® system could only detect S-100B in 20 out of 174 urine samples (range 0.02–0.06 μg/L), whereas the Elecsys® test could detect S-100B in 171 samples (range 0.005–0.14 μg/L). No clear relation was observed between the two methods in urine analysis (correlation coefficient 0.60).

Conclusion: The Sangtec® and Elecsys® assays are not interchangeable methods when analyzing S-100B in serum or urine samples after head injury.

Clin Chem Lab Med 2008;46:1025–9.

Keywords: head trauma; methods; protein S-100B; serum analysis; urine analysis

About the article

Corresponding author: Mikael Bergenheim, MD, PhD, Associate Professor, Department of Surgery, Central Hospital Karlstad, Rosenborgsgatan, 651 85 Karlstad, Sweden Phone: +46-54-615672, Fax +46-54-158316,

Received: 2007-11-27

Accepted: 2008-03-20

Published in Print: 2008-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 46, Issue 7, Pages 1025–1029, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.190.

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